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Table 5 Summary of 3 way integrated analysis of Gene-Expression-SNP and triptolide cytotoxicity (p < 0.0001)

From: Genome-wide association analysis identified splicing single nucleotide polymorphism in CFLAR predictive of triptolide chemo-sensitivity

Gene expression (Gene symbol)

Gene description

Association with total # of SNPs (p < 0.0001)

Distribution of SNPs (Chr: number of SNPs)

Distribution of SNPs on gene (Bold indicates Maximum number of SNPs on Gene)

AGL (Chr1)

Amylo-Alpha-1, 6-Glucosidase, 4-Alpha-Glucanotransferase

27

Chr2:1 / Chr4:2 / Ch6:2 / Chr16:22

CHST5/ADAT1/GABARAPL2/LRP2/SCGN/TMEM231

ASCL4 (Chr12)

Achaete-Scute Complex-Like 4

24

Chr6:5 / Chr7:1 / Ch9:1 / Chr16:2 / Chr17:3 / Chr18:12

MPG/ASXL3/ATP6V0A1/EEPD1/MPG/NAGLU

C21orf96/RUNX-IT1 (Chr21)

RUNX1 Intronic Transcript 1 (Non-Protein Coding)

3

Chr5:1 / Chr9:1 / Chr13:1

PDZD2

C9orf19/GLIPR2 (Chr9)

Glioma Pathogenesis-Related Protein 2

20

Chr1:2 / Chr2:6 / Chr5, 7, 11 and 14 : 1 each / Chr8:3 / Chr12:2 / Chr13:3

ARRB1 / CAPN2 / CFLAR/ TP53BP2

CRYGS (Chr3)

crystallin, gamma S

41

Chr1:30 Chr2 and Chr6: 3 each Chr5:2 Chr8, 9 and 14: 1 each

CAMTA1

CTSK (Chr1)

Cathepsin X

19

Chr1,9 and 16:1 each/ Chr5:6/ Chr7, 10 and 17: 2 each/ Chr14: 4 each

CRISPLD2/FHAD1/IDE/PTPRD/RBFOX3/SNX6/SP4

DTX1 (Chr12)

deltex homolog 1 (Drosophila)

31

Chr 6:5 / Chr 9:1 / Chr 14:2 / Chr 21:23

TIAM1

FOXQ1 (Chr6)

Forkhead Box Protein Q1

21

Chr 1:6 / Chr 3:10 / Chr 5 and 6:1 each / Chr 16:3

FLYWCH1/GNG4/PARK2

GABARAPL1 (Chr12)

GABA(A) Receptor-Associated Protein-Like 1

7

Chr 2:5 / Chr 6 and 14:1 each

STRN3

JAK1 (Chr1)

Janus Kinase 1

44

Chr 1:8 / Chr 2, 3, 6 and 10:2 each/ Chr 4, 12 and 13:1 each / Chr 5:12 / Chr 8:3 / Chr 14:10

GPATCH2/ SLC6A15/ TFDP2

MAPKAPK2 (Chr1)

Mitogen-Activated Protein Kinase-Activated Protein Kinase 2

3

Chr11:2 / Chr 5:1

ARRB1/ OPCML

MGC16186 (Chr10)

DPY30 Domain Containing 2

10

Chr 4:4 / Chr 7, 9 and 22:1 each / Chr 10:3

MANBA/ MYO18B

MGC16385 (Chr16)

CENPB DNA-Binding Domains Containing 1

18

Chr 4:4 / Chr 5:2 / Chr 17 and 22:1 each / Chr 14:10

AGXT2L1/ GIP / ITPK1/PDE6A

MTND4 (mitochondrial)

Mitochondrially Encoded NADH Dehydrogenase

16

Chr 1:8 / Chr 4, 6, 8, 9 and 14:1 each / Chr 10:3

GNG4/ GPATCH2/ SH2D4B

MTND5 (mitochondrial)

Mitochondrially Encoded NADH Dehydrogenase 5

10

Chr 9 and 10:1 / Chr 14:8

PTGDR / SH2D4B

MTVR1 (Chr11)

Mammary Tumor Virus Receptor Homolog 1

28

Chr 2:23 / Chr 6 and 10:1 each / Chr 7:3

NIF3L1/ C7orf42/ CFLAR/ FAM126B/NIF3L1/ORC2

MUC15 (Chr11)

Mucin 15, Cell Surface Associated

16

Chr 1:8 / Chr 2:2 / Chr 9, 15 and 21:1 each / Chr 11:3

CAPN2/CGNL1/TP53BP2

MXD4 (Chr4)

MAX dimerization protein 4

13

Chr 2:3 / Chr 4, 5, 10 and 17:1 each / Chr 9:2 / Chr 16:4

MPG/NPRL3/CCDC46/KANK1/USP34

NADSYN1 (Chr11)

NAD Synthetase 1

38

Chr 2:32 / Chr 13:1 / Chr 16:5

ERBB4/ FHAD1/ GPATCH2

PIP5K1B (Chr9)

Phosphatidylinositol 4-Phosphate 5-Kinase Type-1 Beta

75

Chr 1:2 / Chr 2: 65 / Chr 6 and 14:1 each / Chr 7:4 / Chr 13:2

NIF3L1/ ABCC4/ CFLAR/ FAM126B/ GPATCH2/NDUFB3/NIF3L1/ORC2/PPIL3/SMYD3/TSGA14

PODLX2 (Chr3)

podocalyxin-like 2

44

Chr 3 and 20:1 each / Chr 11:39 / Chr 11:3

LDLRAD3

ROPN1 (Chr3)

Rhophilin Associated Tail Protein 1

7

Chr 1:2 / Chr 3:3 / Chr 4 and 13:1

 

SLC35D2 (Chr9)

Solute Carrier Family 35 Member D2

18

Chr 4 and 10:3 each / Chr 5:10 / Chr 13 and 22:1 each

ABLIM2/ MANBA/ TTLL1

TDE1 (Chr20)

Tumor Differentially Expressed 1

39

Chr 1:12 / Chr 2, 10and 14:1 each / Chr 3:6 / Chr 5:9 / Chr 8:7 / Cht 15:2

FHAD1/PPCS/ SMYD3/ZMYND12

TWSG1 (Chr18)

Twisted Gastrulation Protein Homolog 1

8

Chr 2:5 / Chr 6:3

CLK1/ FAM126B/

VIAAT (Chr20)

Solute Carrier Family 32 Member 1

55

Chr 6 and 10:4 each / Chr 12:1 / Chr 13: 3 / Chr 14:41 / Chr 16:2

SNX6/ STRN3/ RSU1

VPS39 (Chr15)

Vacuolar Protein Sorting 39

14

Chr 2, 3 and 5: 3 each / Chr 4, 11, 13, 14 and 22:1 each

ACTN1/ ARRB1/ GRM7/ SEZ6L

 

Total

648

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