Fig. 4

Examples of gene clusters associated with secondary metabolism. Each panel shows loci containing similar set of genes in the ascomycete trunk pathogens associated with synthesis of (a) terpenes, (b) non-ribosomal peptides and (c) polyketides. The loci shown in the figures were not chosen based on their potential orthology across genomes, but solely on the basis of their similar gene cluster composition. Arrows correspond to genes coding for biosynthetic genes (green; TS (a), NRPS (b), and t1PKS), P450s (yellow), transporters (blue), and FAD-binding proteins (orange). Gray arrows correspond to genes predicted to be part of the clusters, but with other annotations, while white arrows correspond to genes outside of the secondary metabolism clusters. Expression levels of T. minima genes measured using RNA-seq are reported as mapped read pileups in each panel (first row in each panel)