Table 1 Protein families assigned to COG functional category E (Amino acid transport and metabolism) that are present in C. sordellii strain 8483 but absent in C. difficile strain 630

COG functional annotation

COG0076E|Glutamate decarboxylase and related PLP-dependent proteins

COG0115EH|Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase

COG0346E|Lactoylglutathione lyase and related lyases

COG0477GEPR|Permeases of the major facilitator superfamily

COG0493ER|NADPH-dependent glutamate synthase beta chain and related oxidoreductases

COG0549E|Carbamate kinase

COG0697GER|Permeases of the drug/metabolite transporter (DMT) superfamily

COG0703E|Shikimate kinase

COG0747E|ABC-type dipeptide transport system, periplasmic component

COG0757E|3-dehydroquinate dehydratase II

COG0804E|Urea amidohydrolase (urease) alpha subunit

COG0831E|Urea amidohydrolase (urease) gamma subunit

COG0832E|Urea amidohydrolase (urease) beta subunit

COG0834ET|ABC-type amino acid transport/signal transduction systems, periplasmic component/domain

COG1104E|Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

COG1410E|Methionine synthase I, cobalamin-binding domain

COG1703E|Putative periplasmic protein kinase ArgK and related GTPases of G3E family

COG1760E|L-serine deaminase

COG2235E|Arginine deiminase

COG2755E|Lysophospholipase L1 and related esterases

COG2856E|Predicted Zn peptidase

COG2866E|Predicted carboxypeptidase

COG2986E|Histidine ammonia-lyase

COG2987E|Urocanate hydratase

COG3033E|Tryptophanase

COG3191EQ|L-aminopeptidase/D-esterase

COG3227E|Zinc metalloprotease (elastase)

COG3643E|Glutamate formiminotransferase

COG4401E|Chorismate mutase

COG4448E|L-asparaginase II

COG4608E|ABC-type oligopeptide transport system, ATPase component

COG0141E|Histidinol dehydrogenase