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Table 1 Ten most correlated genes with PC1. Tables a and b are subsets of significantly correlated genes with relevant functions in skin lineage (for full data, see Additional file 9: Table S6). a Positively correlated genes, which were upregulated in SGs, and (b) negatively correlated genes, which were upregulated in KCs and HaCaTs

From: Gene expression analysis of skin grafts and cultured keratinocytes using synthetic RNA normalization reveals insights into differentiation and growth control

Gene Symbol

Score

Local FDR

 

(a)

   

RAB11FIP1

0.934

0.00044

 

KRT80

0.933

0.00045

Localization around desmosomal plaques in earlier stages of differentiation [PMID:20843789]

ID4

0.915

0.00052

Lack of the protein in parakeratotic cells at upper skin layer [PMID:21663940]

PPL

0.911

0.00053

A component of desmosomes and of the cornified envelope [PMID:9412476]

KRT1

0.911

0.00054

Specifically expressed in the spinous and granular layers [PMID:10511477]

BCL6

0.900

0.00058

Expression at the terminal differentiation stage [PMID:8912662]

ERBB3

0.897

0.00059

Skin biopsy expressed more than the cultured cells [PMID:11571634]

PLAC2

0.896

0.00059

lncRNA controlling terminal differentiation [PMID:23201690]

PKP1

0.896

0.00059

Localization around desmosomal plaques and nuclei [PMID:16632867]

KRT10

0.894

0.00060

Specifically expressed in the spinous and granular layers [PMID:10511477]

(b)

   

PRDX3

−0.922

0.00044

Mitochondrial [PMID:17893648]

SEC61G

−0.914

0.00045

 

NDUFB3

−0.914

0.00052

Mitochondrial [PMID:12611891]

FXC1

−0.913

0.00053

Mitochondrial [PMID:14726512]

ATP5J

−0.911

0.00054

Mitochondrial [PMID:12110673]

GNG10

−0.911

0.00058

 

TXNDC9

−0.911

0.00059

 

MRPS23

−0.910

0.00059

Mitochondrial ribosomal protein

ENY2

−0.910

0.00059

 

PSMB2

−0.909

0.00060