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Table 4 Gene Ontology analysis for STAT3-deregulated miRNA (combined and individual predictions)

From: HIV-1 gp120 influences the expression of microRNAs in human monocyte-derived dendritic cells via STAT3 activation

Gene Ontology ID

Gene Ontology Term

No. of genes

%

p-value

Corrected p-value (FDR)

Target genes for miR-155

GO:0006350

transcription

246

16.8

1.06E-11

1.93E-08

GO:0045449

regulation of transcription

288

19.7

6.23E-11

1.13E-07

GO:0051252

regulation of RNA metabolic process

201

13.8

1.30E-07

2.35E-04

GO:0006355

regulation of transcription, DNA-dependent

197

13.5

1.57E-07

2.85E-04

Target genes for miR-181b

GO:0045449

regulation of transcription

488

18.7

7.49E-13

1.40E-09

GO:0006350

transcription

406

15.6

2.00E-12

3.75E-09

GO:0051252

regulation of RNA metabolic process

345

13.2

1.05E-09

1.97E-06

GO:0006355

regulation of transcription, DNA-dependent

338

13.0

1.32E-09

2.47E-06

Combined target genes for miR-21, miR-155 and miR-181b

GO:0006350

transcription

647

15.3

1.13E-19

2.15E-16

GO:0045449

regulation of transcription

772

18.2

4.94E-19

9.40E-16

GO:0051252

regulation of RNA metabolic process

539

12.7

9.54E-13

1.82E-09

GO:0006355

regulation of transcription, DNA-dependent

527

12.4

1.92E-12

3.66E-09

GO:0016481

negative regulation of transcription

154

3.6

1.88E-07

3.57E-04

GO:0010629

negative regulation of gene expression

166

3.9

2.28E-07

4.34E-04

GO:0045934

negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

163

3.8

3.00E-06

5.72E-3

GO:0051172

negative regulation of nitrogen compound metabolic process

164

3.9

4.54E-06

8.64E-3

GO:0031327

negative regulation of cellular biosynthetic process

175

4.1

5.03E-06

9.57E-3

GO:0010558

negative regulation of macromolecule biosynthetic process

171

4.0

5.71E-06

1.09E-2

GO:0009890

negative regulation of biosynthetic process

176

4.2

1.29E-05

2.45E-2

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

92

2.2

1.81E-05

3.45E-2

GO:0007167

enzyme linked receptor protein signaling pathway

113

2.7

1.97E-05

3.75E-2

GO:0006357

regulation of transcription from RNA polymerase II promoter

215

5.1

2.18E-05

4.16E-2

  1. The table shows the Gene Onthology terms obtained after the bioinformatics analysis on the genes targeted by STAT3-regulated miRs, taken individually or in combination