Fig. 7

Summary of B. pseudomallei genes that contribute to biofilm development. a In response to varied environmental signals, B. pseudomallei regulates the two-component signal (TCS) transduction system to adapt to environmental changes, by (b) transcribing genes that encode proteins involved in the alteration of surface components and components crucial to initiate attachment of planktonic bacterial cells to solid surfaces for microcolony formation. As the biofilm grows, an oxygen-limited environment forms. c The high biofilm producing B. pseudomallei strain utilises nitrate for anaerobic growth through the denitrification enzyme pathway. Arrow represents activator connection; solid lines represent direct activation; dashed lines represent indirect activation. The boxes and fonts highlighted in red depict the up-regulated biological processes and genes, respectively, while the box highlighted in green depicts the down-regulated biological processes