Core oxidative stress response in Aspergillus nidulans

Emri, Tamás; Szarvas, Vera; Orosz, Erzsébet; Antal, Károly; Park, HeeSoo; Han, Kap-Hoon; Yu, Jae-Hyuk; Pócsi, István

doi:10.1186/s12864-015-1705-z

BMC Genomics

Table 3 Number of co-regulated genes in stress-exposed control and ΔatfA cultures

From: Core oxidative stress response in Aspergillus nidulans

Transcriptional changes^a	Stress exposures^b
Transcriptional changes^a	MSB	MSB tBOOH	MSB tBOOH diamide	MSB tBOOH diamide + h-H₂O₂	MSB tBOOH diamide + NaCl	MSB tBOOH diamide + h-H₂O₂ and NaCl	All^c
THS30.3 control strain
Up-regulated genes
>2x increases in 6 stresses							7
>2x increases in 5 stresses						51	88
>2x increases in 4 stresses				161	84	226	221
>2x increases in 3 stresses			393	414	503	535	523
>2x increases in 2 stresses		699	793	856	1031	1012	1004
>2x increase in 1 stress	1574	1542	2052	2018	2007	1925	1923
Sum:	1574	2241	3238	3449	3625	3749	3766
	MSB only	tBOOH only	Diamide only	h-H₂O₂ only	NaCl only		l-H₂O₂ only
>2x increases	1574	1366	1877	799	1097		153
Down-regulated genes
>2x decreases in 6 stresses							6
>2x decreases in 5 stresses						65	84
>2x decreases in 4 stresses				103	194	278	300
>2x decreases in 3 stresses			480	530	544	543	580
>2x decreases in 2 stresses		786	960	1021	985	1031	1069
>2x decrease in 1 stress	1696	1563	1799	1904	1813	1852	1763
Sum:	1696	2349	3239	3558	3536	3769	3802
	MSB only	tBOOH only	Diamide only	h-H₂O₂ only	NaCl only		l-H₂O₂ only
>2x decreases	1696	1441	2022	789	1032		317
TNJ 92.4 ΔatfA strain
Up-regulated genes
>2x increases in 6 stresses							8
>2x increases in 5 stresses						39	63
>2x increases in 4 stresses				192	69	233	235
>2x increases in 3 stresses			289	331	379	387	399
>2x increases in 2 stresses		561	850	834	951	939	1006
>2x increase in 1 stress	1001	1781	2103	2104	2138	2141	2149
Sum:	1001	2342	3242	3461	3534	3739	3860
	MSB only	tBOOH only	Diamide only	h-H₂O₂ only	NaCl only		l-H₂O₂ only
>2x increases	1001	1902	1767	863	774		354
Down-regulated genes
>2x decreases in 6 stresses							10
>2x decreases in 5 stresses						111	123
>2x decreases in 4 stresses				290	163	289	310
>2x decreases in 3 stresses			440	360	552	531	546
>2x decreases in 2 stresses		740	918	882	850	779	823
>2x decrease in 1 stress	1050	1354	1523	1510	1516	1497	1489
Sum:	1050	2094	2881	3042	3081	3207	3301
	MSB only	tBOOH only	Diamide only	h-H₂O₂ only	NaCl only		l-H₂O₂ only
>2x decreases	1050	1784	1845	835	845		329

^aNumbers of genes with at least two-fold increase or decrease in their transcriptions under the specified stress conditions are presented for both the control and the ΔatfA strains
^bStressor concentrations are presented in footnotes to Table 2
^cMSB, tBOOH, diamide, l-H₂O₂, h-H₂O₂ and NaCl stress treatments

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ISSN: 1471-2164

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