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Table 6 Stress dependent regulation of secondary metabolite genes and clusters

From: Core oxidative stress response in Aspergillus nidulans

 

Stress exposuresa

 

None

MSB

L-H2O2

H-H2O2

tBOOH

Diamide

NaCl

All

THS30.3 control strain

Up-regulation

        

Key genesb

-

11

2**

5

16

16

4

29

All genesc

-

65

17**

25**

65

71

34**

155

Clustersd

-

2

0

0

3

1

0

5

Down-regulation

        

Key genes

-

11

3

8

8

8

9

19

All genes

-

46

22

37

38***

52

39

112

Clusters

-

5

1

0

1

3

2

7

TNJ 92.4 ΔatfA strain

Up-regulation

        

Key genes

-

16

15*

16*

11

11

1

42

All genes

-

53

48*

68*

60

54

29

179

Clusters

-

2

3

2

2

0

0

7

Down-regulation

        

Key genes

-

5***

3***

5***

19*

20*

17***

31

All genes

-

16*,***

22***

26***

71*

82*

70*,***

139

Clusters

-

0

1

2

5

7***

5

9

TNJ 92.4 (ΔatfA) vs. THS30.3 (control)

Up-regulation

        

Key genes

11

       

All genes

43

       

Clusters

4

       

Down-regulation

        

Key genes

5

       

All genes

22***

       

Clusters

0

       
  1. *Significant difference between the THS30.3 control and TNJ 92.4 (ΔatfA) strain according to the Fisher’s exact test (p < 0.05; nkey genes = 94, nall genes = 467, nclusters = 66)
  2. **Significant difference in comparison to MSB, tBOOH and diamide treatment as well (in the same row) according to the Fisher’s exact test (p < 0.05; nkey genes = 94, nall genes = 467, nclusters = 66)
  3. ***Significant difference between the up- and down-regulated genes according to the Fisher’s exact test (p < 0.05; nkey genes = 94, nall genes = 467, nclusters = 66)
  4. aStressor concentrations are presented in footnotes to Table 2
  5. bKey genes were defined as secondary metabolite cluster genes encoding transcription factors, non-ribosomal peptide synthases, polyketide synthases, terpene synthase or prenyltransferases according to Inglis et al. [114]
  6. cOnly genes of clusters determined either manually or experimentally were involved in the analysis [114]
  7. dClusters were regarded as up-regulated (or down-regulated) cluster if at least one of its key genes and more than half of its manually or experimentally determined genes were up-regulated (down-regulated)
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BMC Genomics

ISSN: 1471-2164

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