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Table 1 Suppressors of Q56-YFP toxicity

From: Polyglutamine toxicity in yeast induces metabolic alterations and mitochondrial defects

Gene knockout

Strain number

Gene function

Growth of Q56-YFP

arg82Δ

3531

Inositol polyphosphate multikinase (IPMK)

--

atp15Δ

1021

Epsilon subunit of mitochondrial ATP synthase

--

cem1Δ

198

Mitochondrial beta-keto-acyl synthase

--

his7Δ

3388

Imidazole glycerol phosphate synthase

---

hom6Δ

6933

Homoserine dehydrogenase

--

ies2Δ

1997

Essential for growth under anaerobic conditions

--

kre28Δ

4366

Subunit of a kinetochore-microtubule binding complex

--

map1Δ

5153

Methionine aminopeptidase

--

ncl1Δ

3050

S-adenosyl-L-methionine-dependent tRNA

---

nfu1Δ

4889

Protein involved in iron metabolism in mitochondria

--

rpb9Δ

4437

RNA polymerase II subunit

--

rrn10Δ

3051

Subunit of UAF (upstream activation factor) for RNA polymerase I

---

ugo1Δ

4304

Outer membrane component of the mitochondrial fusion machinery

--

ybr196c-aΔ

7457

Putative protein of unknown function

--

  1. Genes, whose knock-out leads to an enhanced phenotype. The intensity of the phenotype is indicated on a semi-quantitative scale. --- : very strong toxicity, no residual growth, --: residual growth detectable, but stronger toxicity than in the WT background. Gene functions are annotated according to the yeast genome database