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Fig. 4 | BMC Genomics

Fig. 4

From: Characterizing 5-hydroxymethylcytosine in human prefrontal cortex at single base resolution

Fig. 4

5hmC was enriched in the gene bodies of highly expressed genes and at exon-intron boundaries. a 5hmC density was plotted against genomic location for all genes separated in quartiles by their expression levels. 5hmC showed the greatest decrease in density at the TSS for highly expressed genes, while also showing the greatest increase in density in the gene body for this same group. The opposite trend was seen in genes in the lowest quartile of expression. An interesting spike in 5hmC density was also observed at the TES in all quartiles of expression. b 5hmC density is increased in the exons on the 5’ and 3’ ends of exon-intron boundaries. c A similar pattern of 5hmC density was also seen on the anti-sense strand of corresponding exon-intron boundaries. (TSS = transcription start site; TES = transcription end site)

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