Fig. 5
Comparison of genes upregulated in rat and mouse prion disease. a. Orthologous probe sets differentially regulated by 2-fold were identified in both rat and mouse prion disease and the overlap determined. Duplicate probe sets measuring the same gene were eliminated for simplicity. b. Mouse scrapie induced gene expression changes were regressed onto changes induced by rat scrapie. Expression values are log2 transformed. The grey box indicates those orthologs whose expression is not changed >2-fold. Expression of probe sets that lie along the axes are highly divergent in prion disease between mice and rats. Stricter bioinformatic mapping of orthologous pairs did not meaningfully improve the regression