Fig. 4
Enrichment in selected synapse-related BP GO terms as the classification threshold increases. a–d show the enrichment of the catalogues generated by each classifier, in a representative selection of GO terms of relevance for the biological function “synapse”. For all classifiers, elevation of the threshold resulted in increased enrichment. This increase in functional enrichment is accentuated in the consensus catalogues, showing how the combined methods improved the three individual classifiers. a k-NN catalogues, b Random Forest catalogues, c SVM catalogues, d catalogues of genes classified as synaptic by the three classifiers. All enrichment values have an associated p-value lower than 10−4 and a FDR q-value lower than 10−3