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Table 1 Putative synaptic genes with no synapse-related annotation in Drosophila and homologues annotated as synaptic in Homo sapiens

From: Putative synaptic genes defined from a Drosophila whole body developmental transcriptome by a machine learning approach

Annotation symbol

Gene symbol

Mean prob.

Human homologue

HGI

GO term (in Homo sapiens)

CG7392

Cka

1.00

STRN

ENSG00000115808

CC: postsynaptic membrane

CG9634

NA

1.00

MME

ENSG00000196549

CC: synaptic vesicle

CG8529

Dyb

0.99

DTNA

ENSG00000134769

BP: synaptic transmission

CG7023

Usp12–46

0.99

USP46

ENSG00000109189

BP: regulation of synaptic transmission

CG16973

msn

0.99

MINK1

ENSG00000141503

BP: synaptic transmission

CG6593

Pp1alpha-96A

0.99

PPP1CA

ENSG00000172531

CC: dendritic spine

CG15112

ena

0.99

ENAH

ENSG00000154380

CC: synapse

CG10545

Gbeta13F

0.99

GNB2

ENSG00000172354

BP: synaptic transmission

CG14991

Fit1

0.99

FERMT1

ENSG00000101311

CC: synapse

CG1651

Ank

0.99

ANK2

ENSG00000145362

CC: postsynaptic membrane

CG32717

sdt

0.99

MPP4

ENSG00000082126

CC: presynaptic membrane

CG5248

loco

0.99

RGS14

ENSG00000169220

BP: long-term synaptic potentiation

CG7147

kuz

0.99

ADAM10

ENSG00000137845

CC: postsynaptic density

CG10566

NA

0.99

ICA1

ENSG00000003147

CC: synaptic vesicle membrane

CG32264

NA

0.99

PHACTR1

ENSG00000112137

CC: synapse

CG13830

NA

0.99

SPOCK2

ENSG00000107742

BP: synapse assembly

CG10637

Nak

0.98

AAK1

ENSG00000115977

CC: terminal bouton (of the axon)

CG3269

Rab2

0.98

RAB14

ENSG00000119396

BP: neurotransmitter secretion

CG10011

NA

0.98

ANK2

ENSG00000145362

CC: postsynaptic membrane

CG8440

Lis-1

0.98

PAFAH1B1

ENSG00000007168

BP: synaptic transmission

CG5650

Pp1-87B

0.98

PPP1CA

ENSG00000172531

CC: dendritic spine

CG10579

Eip63E

0.98

CDK16

ENSG00000102225

CC: synaptic vesicle

CG10538

CdGAPr

0.98

ARHGAP32

ENSG00000134909

CC: postsynaptic membrane

CG7535

GluClalpha

0.98

CHRNA5

ENSG00000169684

BP: synaptic transmission

CG8726

NA

0.98

PXK

ENSG00000168297

BP: regulation of synaptic transmission

CG30389

NA

0.98

TMEM57

ENSG00000204178

CC: synapse part

CG7546

NA

0.98

BAG6

ENSG00000204463

BP: synaptonemal complex assembly

CG1506

Ac3

0.98

ADCY3

ENSG00000138031

BP: synaptic transmission

CG6214

MRP

0.98

ABCC8

ENSG00000006071

BP: synaptic transmission

CG4574

Plc21C

0.98

PLCB1

ENSG00000182621

BP: synaptic transmission

CG11734

HERC2

0.98

HERC1

ENSG00000103657

MF: neurotrans:Na symporter activity

CG42829

CadN2

0.97

CDH2

ENSG00000170558

CC: synapse

CG6383

crb

0.97

DNER

ENSG00000187957

BP: synapse assembly

CG1862

Ephrin

0.97

EFNB1

ENSG00000090776

CC: synapse

CG7100

Cadherin-N

0.97

CDH1

ENSG00000039068

BP: synapse assembly

CG8948

Graf

0.97

OPHN1

ENSG00000079482

BP: synaptic vesicle endocytosis

CG9361

Task7

0.97

KCNK3

ENSG00000171303

BP: synaptic transmission

CG6998

ctp

0.97

DYNLL2

ENSG00000121083

BP: synaptic target recognition

CG18455

Optix

0.97

SIX1

ENSG00000126778

BP: reg. of synaptic growth at nj

CG5912

arr

0.96

LRP6

ENSG00000070018

BP: synaptic transmission CC: synapse

CG8261

Ggamma1

0.96

GNG10

ENSG00000242616

BP: synaptic transmission

CG2849

Rala

0.96

RIT2

ENSG00000152214

BP: synaptic transmission

CG32217

Su(Tpl)

0.96

MARVELD2

ENSG00000152939

MF: neurotrans:Na symporter activity

CG17336

Lcch3

0.96

GABRB1

ENSG00000163288

BP: synaptic transmission

CG15274

GABA-B-R1

0.96

GABBR1

ENSG00000204681

BP: synaptic transmission

CG4244

Su(dx)

0.96

NEDD4

ENSG00000069869

BP: regulation of synapse organization

CG16757

Spn

0.96

PPP1R9A

ENSG00000158528

CC: synapse

CG4625

Dhap-at

0.96

GNPAT

ENSG00000116906

BP: synapse assembly

CG32434

siz

0.96

IQSEC3

ENSG00000120645

CC: inhibitory synapse

CG9491

Gef26

0.95

RAPGEF2

ENSG00000109756

BP: regulation of synaptic plasticity

CG42314

PMCA

0.95

ATP2B2

ENSG00000157087

BP: regulation of synaptic plasticity

CG7223

htl

0.95

FGFR2

ENSG00000066468

BP: synaptic vesicle transport

CG9375

Ras 85D

0.95

HRAS

ENSG00000174775

BP: long-term synaptic plasticity

CG30388

Magi

0.95

MAGI2

ENSG00000187391

CC: synapse

CG11958

Cnx99A

0.95

CANX

ENSG00000127022

BP: synaptic vesicle endocytosis

CG9985

sktl

0.94

PIP5K1C

ENSG00000186111

BP: synaptic vesicle exo and endocitosis

CG8726

NA

0.94

KCNK18

ENSG00000186795

BP: synaptic transmission

CG7641

Nca

0.94

NCALD

ENSG00000104490

BP. synaptic transmission

CG8394

VGAT

0.94

SLC32A1

ENSG00000101438

BP: synaptic transmission

CG3585

Rbcn-3A

0.94

DMXL2

ENSG00000104093

CC: synaptic vesicle

CG7558

Arp3

0.94

ACTR3

ENSG00000115091

CC: excitatory synapse

CG14145

Blos2

0.94

BLOC1S2

ENSG00000196072

BP: synaptic vesicle transport

CG1407

NA

0.94

ZDHHC15

ENSG00000102383

BP: synaptic vesicle maturation

CG31196

14-3-3epsilon

0.94

YWHAE

ENSG00000128245

BP: regulation of synaptic plasticity

CG16928

mre11

0.94

MRE11A

ENSG00000020922

CC: synapsis

CG8705

pnut

0.92

SEPT5

ENSG00000184702

BP: synaptic vesicle targeting

  1. The table shows the list of Drosophila genes belonging to our final catalogue of putative synaptic genes that don’t have any synapse related GO term annotation but have at least 1 homologue in Homo sapiens already annotated with some synapse related GO term. The first 2 columns show the Annotation Symbol as well as the Symbol of these 66 Drosophila genes. The third column shows the mean between the classification probabilities given by the three learning algorithms to each gene. The following columns show the symbol and gene identifier of the corresponding human homologue (or 1 of them when there are more than 1) that is already annotated with at least 1 synapse related GO term in humans, an annotation that is shown in the last column of the table