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Fig. 8 | BMC Genomics

Fig. 8

From: A survey of tandem repeat instabilities and associated gene expression changes in 35 colorectal cancers

Fig. 8

Genes with repeat instability are dysregulated in the Wnt, MAPK and p53 pathways. Box plot of binary logarithm of mean expression levels of those genes with repeat instability (copy number variation, repeat gain, or repeat loss) (left box in each pair) and of genes without repeat instability (right box) in tumor genomes, for genes in the Wnt (n = 32, for both boxes), TGF beta (n = 6), MAPK (n = 19), mTOR (n = 38) and p53 (n = 31) signaling pathways. Thick horizontal lines in each box mark the median, edges of boxes correspond to the 25th and 75th percentiles, and whiskers cover 99.7 % of the data’s range. Differences in gene expression are significant for the p53 (WSR test after Bonferroni correction P < 10−4), MAPK (P < 10−5) and Wnt signaling pathways (P = 0.03)

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