|  | Differential expression of tRNA MDS vs control | Linear regression association of tRNA with response | ||||
---|---|---|---|---|---|---|---|
tRNA | Association | pAdj (DESeq2) | pAdj (edgeR) | pAdj (baySeq) | Effect | Std err | p value |
MT-TF | MELAS, MT-TF-related, MERRF syndrome [88] | 0.0103 | 0.0015 | 0.4869 | −1.3378 | 3.5754 | 0.7129 |
MT-TV | Leigh syndrome, NARP, mitochondrial disorder [89] | 0.0103 | 0.0020 | 0.6661 | −0.1755 | 0.2952 | 0.5602 |
MT-TL1 | myelodysplastic syndrome [39] | 0.0299 | 0.0030 | 0.4143 | 0.7728 | 1.1559 | 0.5127 |
MT-TI | hypertrophic cardiomyopathy [90] | 0.0431 | 0.0044 | 0.7070 | −1.3977 | 2.8147 | 0.6258 |
MT-TQ | MELAS [91] | 0.4745 | 0.0687 | 0.9095 | −0.1673 | 0.2261 | 0.4693 |
MT-TM | mitochondria disorder, hypertension [92] | NA | 0.0354 | 0.6065 | −0.6015 | 0.2818 | 0.0476 |
MT-TW | neonatal onset mito disease [93] | 0.0271 | 0.0040 | 0.4824 | −18.3065 | 27.0968 | 0.5084 |
MT-TA | hearing loss [94] | 0.0062 | 0.0015 | 0.2336 | −33.3062 | 19.0142 | 0.0979 |
MT-TN | Ophthalmoplegia [95] | 0.0134 | 0.0024 | 0.5159 | −6.6839 | 3.0347 | 0.0417 |
MT-TC | hearing loss [96] | 0.0006 | 0.0005 | 0.0011 | −0.7931 | 1.1525 | 0.5006 |
MT-TY | mitochondrial cytopathy [97] | 0.5648 | 0.0642 | 0.9019 | 0.0994 | 3.1135 | 0.9749 |
MT-TS1 | hearing loss [98] | 0.0017 | 0.0009 | 0.1043 | −54.1283 | 17.2749 | 0.0061 |
MT-TD | mitochondrial myopathy [99] | NA | 0.1135 | 0.8845 | −14.0023 | 9.2086 | 0.1467 |
MT-TK | MELAS [100] | 0.6851 | 0.1933 | 0.9098 | −0.4508 | 0.5028 | 0.3825 |
MT-TG | hypertrophic cardiomyopathy [101] | 0.0775 | 0.0067 | 0.7119 | 0.4488 | 4.0525 | 0.9131 |
MT-TR | mitochondria myopathy [102] | 0.4745 | 0.1346 | 0.8194 | −19.9639 | 10.4921 | 0.0742 |
MT-TH | MELAS [103] | 0.1634 | 0.0251 | 0.8843 | −0.4952 | 0.4202 | 0.2549 |
MT-TS2 | mitochondrial myopathy [104] | 0.0431 | 0.0043 | 0.8107 | −0.0547 | 0.2504 | 0.8295 |
MT-TL2 | ophthalmoplegia [105] | 0.3483 | 0.0534 | 0.9062 | −1.1874 | 1.2812 | 0.3670 |
MT-TE | myopathy [106] | 0.0271 | 0.0045 | 0.5381 | −0.3868 | 0.2411 | 0.1271 |
MT-TT | multiple sclerosis [107] | 0.3483 | 0.0466 | 0.8629 | −9.0631 | 11.8617 | 0.4553 |
MT-TP | mitochondrial catopathy [108] | 0.0034 | 0.0007 | 0.4374 | −4.2378 | 3.7122 | 0.2694 |