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Fig. 1 | BMC Genomics

Fig. 1

From: A maximum-likelihood approach for building cell-type trees by lifting

Fig. 1

Flowchart for building cell-type trees using a maximum-likelihood framework. Data preprocessing: the mapped reads in the ChIP-Seq data are used to find peaks in the data. Data representation: peak data is converted to a binary matrix using windowing/overlap representation. Phylogenetic analysis: using distance-based, parsimony-based or maximum-likelihood-based phylogenetic approach. Inferring ancestral or internal nodes: we establish a parent-child relationship between the cell types (leaf data) using a process called lifting

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