Fig. 8

TrmBL1 controls expression of genes involved in functionally-linked metabolic pathways by its own or in concert with secondary regulators. TrmBL1 mediated repression or activation is depicted in red or blue. Complete colouring indicates validation of repression or activation by cell-free transcription. Banded colouring indicates suggested transcriptional effects. Genes differentially expressed in a microarray analysis of P. furiosus grown on maltose or peptides are underlined [54]. Gene products: PF0132, proposed α-glucosidase; PF0196, phosphoglucose isomerase; PF0272, proposed 4-α-glucanotransferase; PF0287, pyrolysin; PF0464, glycerinaldehyde 3-phosphate:ferredoxin oxidoreductase; PF0477, proposed extracellular α-amylase. PF0478, proposed extracellular cyclomaltodextrin glucano-transferase; PF0505, putative DNA binding protein; PF0588, phosphoglucose mutase; PF0853, 5'-methylthioadenosine phosphorylase; PF0874, membrane dipeptidase; PF0967-PF0965, pyruvate ferredoxin oxidoreductase; PF1109/1110, extracellular starch-binding protein; PF1350, proposed single-component transport protein; PF1476, putative PadR-like regulator; PF1535, maltodextrin phosphorylase; PF1539, dihydroorotate dehydrogenase 1b; PF1784, phosphofructokinase; PF1874 glycerinaldehyde 3-phosphate dehydroghenase; PF1920, triosephosphate isomerase; PF1935, amylo-pullulanase; PF1938-PF1933 maltodextrin-specific ABC transporter (MD-system); PF1956 phosphoglycerate mutase; PF1959, fructose-1,6-bisphosphate aldolase; PF2016, preprotein translocase subunit SecG; PF2047, L-asparaginase. AA; amino acid