Fig. 1From: cnvScan: a CNV screening and annotation tool to improve the clinical utility of computational CNV prediction from exome sequencing dataCumulative TP (cTP) count and cumulative FP (cFP) count distribution for five programs tested in the study. a cTP count vs cFP count for each quality score of the prediction program. b, c, d cTP count distribution vs CNV quality score. e, f, g cFP count distribution vs CNV quality score. h, i, j False Discovery Rate (FDR) vs CNV quality score for five programs. FDR: False positive CNVs/(True positive CNVs + False positive CNVs). All the programs showed a decrease in FDR with increasing quality score (Pearson correlation coefficients (r) - ExomeCopy: r = −0.49, p = 2.50e-21; ExCopyDepth: r = −0. 56, p = 1.44e-74; ExomeDepth: r = −0.64, p = 7.82e-105; CoNIFER: r = −0.63, p = 0.00; XHMM: r = −0.98, p = 4.34e-269). Quality scores of different prediction programs have different ranges, therefore scores are presented in different figures. CoNIFER SVD-ZRPKM values range from −3 - +3, thus absolute values are presented in Fig. 1c, f Back to article page