Skip to main content
Fig. 5 | BMC Genomics

Fig. 5

From: Multi-omic measurement of mutually exclusive loss-of-function enriches for candidate synthetic lethal gene pairs

Fig. 5

The SMARCA4 and SMARCA1 synthetic lethal pairing. a The expression distribution of SMARCA4 and SMARCA1 across 811 CCLE cell lines. This pair was detected by BiGEE as the two genes are never expressed at low levels together (below the bimodal midpoint of expression). b The expression distribution of SMARCA1 (orange) coloured by SMARCA4 loss (black). This pair was also detected by the BEEM tool (with copy number data). SMARCA4 loss is enriched where SMARCA1 expression is high. This is indicative of possible interdependency. c The ATARIS phenotype dependency scores for cell lines on the SMARCA4 gene. The cell lines are split based on expression loss of SMARCA1. The boxplot labeled 0 has SMARCA1 expression loss, and the boxplot labeled 1 has SMARCA1 normal expression. Cell lines appear more dependent on SMARCA4 when SMARCA1 is lost indicating synthetic lethality. Data is from the Hoffman epigenetic screen. d The biological rationale for synthetic lethality. SMARCA4 and SMARCA1 functionally redundant domains and gene ontology terms

Back to article page