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Fig. 6 | BMC Genomics

Fig. 6

From: Multi-omic measurement of mutually exclusive loss-of-function enriches for candidate synthetic lethal gene pairs

Fig. 6

The KLHL9 and NSD1 synthetic lethal pairing. a The KLHL9 and NSD1 synthetic lethal pairing as seen by the gene expression workflow. The pair shows an almost complete mutually exclusive loss of expression across 811 cell lines (only the KS1 cell line prevents total mutually exclusive loss at the expression level). b The expression distribution of KLHL9 (orange) coloured by NSD1 mutation (black). This pair was detected by the genomic workflow (BEEM). NSD1 loss is exclusive where KLHL9 expression is high. This is indicative of possible interdependency. c The ATARIS phenotype dependency scores for cell lines on the NSD1 gene. The cell lines are split based on expression loss of KLHL9. The boxplot labeled 0 has KLHL9 expression loss, and the boxplot labeled 1 has SMARCA1 normal expression. Cell lines are more dependent on NSD1 when KLHL9 is lost indicating synthetic lethality. Data is from the Hoffman epigenetic screen

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