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Table 3 Genes shared between 3 weeks diapause and aging in Drosophila

From: Slowed aging during reproductive dormancy is reflected in genome-wide transcriptome changes in Drosophila melanogaster

Symbol

Gene name

3wD (logFC)

Longevity effect

ry

rosy

2.4

pro

Nlaz

Neural Lazarillo

2.38

pro

to

takeout

2.21

pro

Zw

Zwischenferment

2.18

pro

elav

embryonic lethal abnormal vision

1.83

pro

bsk

basket

1.69

pro

GstS1

Glutathione S transferase S1

1.68

pro

Nf1

Neurofibromin 1

1.63

pro

CG1623

hebe

1.54

pro

Mlp84B

Muscle LIM protein at 84B

1.45

pro

CG11546

kermit

1.43

pro

CG8846

Thor

1.3

pro

Ilp6

Insulin-like peptide 6

1.17

pro

cher

cheerio

1.13

pro

rut

rutabaga

1.01

pro

srl

spargel

−1.06

pro

bam

bag of marbles

−1.18

pro

Daxx

Daxx-like protein

−1.4

pro

POSH

Plenty of SH3s

−1.42

pro

CG5671

Pten

−1.71

pro

Mt2

Methyltransferase 2

−2.14

pro

Hsp26

Heat shock protein 26

−2.89

pro

Hsp27

Heat shock protein 27

−3.15

pro

CG6284

Sirt6

−3.41

pro

a-Man-Ia

alpha Mannosidase I

2.01

anti

Ilp2

Insulin-like peptide 2

1.9

anti

E(z)

Enhancer of zeste

−1

anti

snz

snazarus

−1.2

anti

Edem1

ER degradation enhancer mannosidase alpha-like 1

−1.35

anti

kuk

kugelkern

−1.36

anti

LBR

Lamin B receptor

−1.91

anti

CG6824

ovo

−1.98

anti

esc

extra sexcombs

−2.44

anti

Hsp22

Hsp22

−1.13

both

  1. Notes: During diapause 34 genes out of 136 hits for aging genes in GenAge database were found to be significantly regulated (q < 0.05, |logFC| > 1). Comparison with the GenAge database [133, 134] http://genomics.senescence.info/genes/