Fig. 4

Quantile-quantile plots and histograms for the second data set under the null hypothesis. The p-value distributions on the Yatsunenko dataset with no added effect and a group size of 6 + 6 averaged over 100 resampled metagenomes. For the quantile-quantile-plots, each grey line represent a resampled metagenome, the solid black line represents the average value and the dotted line the line with slope one corresponding to a uniform p-value distribution. The panels correspond to edgeR (a), DESeq2 (b), overdispersed Poisson GLM (c), metagenomeSeq (d), metastats (e) and voom (f). (See Additional file 11: Figure S7 for the additional eight methods)