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Table 1 Differences between the properties of human small-scale and whole-genome duplicate pairs in different dN ranges. Pair wise two-tailed Mann–Whitney U test were used to compare the means of SSD and WGD pairs within each group

From: Global analysis of human duplicated genes reveals the relative importance of whole-genome duplicates originated in the early vertebrate evolution

Parameter Measured

Database used

Overall

dN 0.0–0.1

dN 0.1–0.2

dN 0.2–0.3

dN 0.3–0.4

dN > 0.4

SSD

WGD

P-value

SSD

WGD

P-value

SSD

WGD

P-value

SSD

WGD

P-value

SSD

WGD

P-value

SSD

WGD

P-value

Functional Similarity between paralogs

Shared GO Terms for Biological Process

x̄= 0.710

x̄= 0.415

<1.00 × 10−6

x̄= 0.734

x̄= 0.499

2.325 × 10−52

x̄= 0.720

x̄= 0.476

5.925 × 10−123

x̄= 0.657

x̄= 0.440

2.892 × 10−120

x̄= 0.726

x̄= 0.413

1.397 × 10−274

x̄= 0.710

x̄= 0.391

1.983 × 10−135

N = 14742

N = 12022

 

N = 3640

N = 414

 

N = 2754

N = 1140

 

N = 3328

N = 2002

 

N = 4264

N = 2192

 

N = 756

N = 6274

Shared GO Terms for Molecular Function

x̄= 0.840

x̄= 0.659

<1.00 × 10−6

x̄= 0.850

x̄= 0.724

6.077 × 10−47

x̄= 0.856

x̄= 0.706

1.075 × 10−129

x̄= 0.810

x̄= 0.696

1.814 × 10−96

x̄= 0.846

x̄= 0.677

4.976 × 10−218

x̄= 0.826

x̄= 0.628

5.072 × 10−107

N = 18584

N = 12392

 

N = 4668

N = 410

 

N = 3510

N = 1188

 

N = 4300

N = 2076

 

N = 5246

N = 2250

 

N = 860

N = 6468

Shared Subcellular Compartment of paralogs

GO Cellular Component

x̄= 0.782

x̄= 0.541

<1.00 × 10−6

x̄= 0.816

x̄= 0.579

5.341 × 10−76

x̄= 0.788

x̄= 0.581

5.652 × 10−119

x̄= 0.740

x̄= 0.541

3.344 × 10−139

x̄= 0.781

x̄= 0.555

1.421 × 10−215

x̄= 0.777

x̄= 0.527

1.156 × 10−100

N = 15248

N = 12198

 

N = 3790

N = 380

 

N = 2914

N = 1162

 

N = 3444

N = 2036

 

N = 4356

N = 2228

 

N = 744

N = 6392

Gene expression profile similarity between paralogs

Human Protein Atlas

x̄= 0.403

x̄= 0.193

<1.00 × 10−6

x̄= 0.615

x̄= 0.254

1.558 × 10−63

x̄= 0.414

x̄= 0.253

1.774 × 10−42

x̄= 0.307

x̄= 0.191

7.331 × 10−32

x̄= 0.316

x̄= 0.190

1.131 × 10−34

x̄= 0.322

x̄= 0.179

1.308 × 10−17

N = 11726

N = 13060

 

N = 2588

N = 426

 

N = 2758

N = 1226

 

N = 2834

N = 2158

 

N = 3042

N = 2366

 

N = 504

N = 6884

Expression Atlas

x̄= 0.450

x̄= 0.216

<1.00 × 10−6

x̄= 0.508

x̄= 0.284

1.032 × 10−30

x̄= 0.457

x̄= 0.280

5.953 × 10−53

x̄= 0.430

x̄= 0.216

1.377 × 10−105

x̄= 0.420

x̄= 0.219

5.471 × 10−96

x̄= 0.394

x̄= 0.199

5.735 × 10−36

N = 15404

N = 13072

 

N = 3628

N = 422

 

N = 3458

N = 1220

 

N = 3792

N = 2166

 

N = 3922

N = 2370

 

N = 604

N = 6894

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BMC Genomics

ISSN: 1471-2164

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