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Table 2 The top 6 gene networks associated with the TBI-I dataset

From: Bilateral gene interaction hierarchy analysis of the cell death gene response emphasizes the significance of cell cycle genes following unilateral traumatic brain injury

Network ID

Molecules in network

Score

Focus molecules

Top diseases and functions

1

CADM1, CALB1, CBFB, CDCA7L, CMIP, Cytochrome bc1, cytochrome-c oxidase, DAB2, DEDD, FGF9, FLNA, FYN, GCLC, GCLM, GFAP, GFRA1, ITGA6, JDP2, MAOA, MED14, MGEA5, NFE2L1, NFE2L2, NPTX1, NRP1, PDHA1, PDLIM7, RET, Rnr, RPS24, RTN4, SLC18A2, Sos, STK17B, TAF4B

46

31

Cell Death and Survival, Drug Metabolism, Molecular Transport

2

AMOT, ANXA1, API5, ATF3, ATG12, BAG3, CCNA2, Cdc2, CDK1, CDK2, CDKN1B, ETV5, FGFR3, FN1, GJA1, Hedgehog, LATS1, MCL1, MCM2, MCM8, MLLT4, MMS22L, NAA15, Patched, PIK3C2A, PKP2, PSMA7, RAB35, RPRM, SPIN1, TAGLN2, THOC2, TJP2, UNC5B, XPO1

46

32

Cell Death and Survival, Cell Cycle, Reproductive System Development and Function

3

AHCTF1, AKAP12, amylase, BCL11A, CA4, CACNA1G, CCND1, CLCN7, CREB1, CREBBP, CSF1, CSRNP1, CTNNB1, DES, Histone h3, IKK (complex), ITPR2, KLF6, KPNB1, MITF, MTMR1, NFIX, PRKD3, PTGR1, RAI14, RNA polymerase II, RRM2, SENP2, SMAD4, SMARCA4, SUDS3, TBL1XR1, TGM2, THRA, ZBTB18

43

31

Cell Death and Survival, Organismal Survival, Gene Expression

4

ABCA1, ALB, ALDH1A2, BTG2, Ccl2, Ccl7, CD36, CEBPB, chemokine, CREM, CXCL3, DUSP5, EGR2, FGF2, FGL2, FOSL1, FSH, Hmgb2 (includes others), HMOX1, IL1, IL12 (family), IL6R, ITGB2, KLF4, MAPK9, NEK6, NEK7, PDE4B, Pld, PRKCI, PTGS2, SPP1, THBD, TLR4, WNT5A

42

30

Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking

5

ACSL5, AGTR2, AMFR, AVP, CAMK2N1, CAPRIN1, CHSY1, CUL5, DCK, ELAVL1, Endothelin, GMCL1, GNRH, Insulin, MAP4K4, MSI2, MTORC1, NEO1, OPA1, Proinsulin, PTGER3, Relaxin, RNF2, SLC2A3, SMAD7, STAG1, TACR1, TCEB3, TMEM123, TRAF6, WAPAL, WFS1, WTAP, ZMYM2, ZNF280B

41

29

Cell Death and Survival, Cardiovascular System Development and Function, Hereditary Disorder

6

26 s Proteasome, ARL11, BCL2L1, CAMK1G, CAMK2D, CASP3, CAV1, CISD2, CLASP1, CLN5, DLG4, EN2, ENC1, Esr1-Esr1-estrogen-estrogen, FBXO9, G2E3, Hsp70, Hsp90, HSP90AB1, IDE, KIF1B, MDM2, PCDH15, PGR, PI4K2A, PRDM2, PSEN1, SGPL1, SNCA, SPTBN1, SRC (family), SRPK2, TMEM109, TRIM2, VPS41

40

30

Cell Death and Survival, Cancer, Neurological Disease

  1. Bold= > Gene included in the dataset
  2. Note: Some of the nodes in the original networks represent gene groups, complexes or families that, when expanded, contain more potential GOI
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BMC Genomics

ISSN: 1471-2164

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