Table 2 The top 20 hypomethylated a-CpGs in middle-aged individuals. The hypermethylated and hypomethylated a-CpGs are shown separately in Tables 1 and 2, respectively. The top-ranking hypomethylated a-CpGs were selected with the following criteria: 1) direction of the association based on the value of beta regression (denoted as ‘betareg’) estimate of age; 2) more than one hit identified per gene (q-value < 0.05 which corresponds to false discovery rate < 5 %) and 3) the top-ranking p-values. The full list of a-CpGs is shown in Additional file 3: Table S4. The q-value denotes the Benjamini-Hochberg-corrected p-value
From: Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study
ProbeID | Gene name | CHR | Coordinate | Betareg estimate of age | q-value |
|---|---|---|---|---|---|
cg00791074 | MTHFD1L | 6 | 151227862 | -0.018 | 7.51E-04 |
cg18618815 | COL1A1 | 17 | 45630323 | -0.018 | 5.99E-03 |
cg14169886 | PRDM16 | 1 | 3101709 | -0.014 | 5.99E-03 |
cg01820374 | LAG3 | 12 | 6752344 | -0.014 | 9.24E-03 |
cg19421125 | LAG3 | 12 | 6753117 | -0.022 | 1.02E-02 |
cg14829066 | NTRK3 | 15 | 86360145 | -0.013 | 1.49E-02 |
cg03290281 | C6orf195 | 6 | 2577606 | -0.021 | 1.49E-02 |
cg05561193 | DCLK2 | 4 | 151218492 | -0.017 | 1.96E-02 |
cg20249566 | NWD1 | 19 | 16691739 | -0.024 | 1.97E-02 |
cg23928726 | PEX10 | 1 | 2334858 | -0.014 | 1.97E-02 |
cg20007894 | SCAND3 | 6 | 28648421 | -0.019 | 2.08E-02 |
cg16355231 | PEX10 | 1 | 2334839 | -0.019 | 2.14E-02 |
cg15058210 | HDAC4 | 2 | 239861814 | -0.018 | 2.16E-02 |
cg06030846 | TMEM108 | 3 | 134581182 | -0.011 | 2.16E-02 |
cg25994988 | UBASH3B | 11 | 122157592 | -0.011 | 2.16E-02 |
cg18345924 | NCAM2 | 21 | 21294102 | -0.016 | 2.18E-02 |
cg00638021 | COL1A1 | 17 | 45622061 | -0.013 | 2.26E-02 |
cg19344626 | NWD1 | 19 | 16691749 | -0.024 | 2.36E-02 |
cg01288258 | ITFG2 | 12 | 2792128 | -0.011 | 2.41E-02 |
cg05221385 | TAF10 | 11 | 6590080 | -0.010 | 2.43E-02 |