Gene symbol | Gene name | a% RPKM abundance | Gene function |
---|---|---|---|
CSN2 | Casein beta | 23.939 | Major milk protein, determine surface properties of casein micelles, source of bioactive peptides and amino acids, mammary gland specific protein |
CSN1S1 | Casein alpha s1 | 20.051 | Major milk protein, antioxidant peptide, plays role in the transport of calcium phosphate, source of bioactive peptides and amino acids, mammary gland specific protein |
LGB (PAEP) | Beta-lactoglobulin (progestagen-associated endometrial protein) | 9.993 | Major milk protein, play role in retinol binding |
CSN1S2 | Casein alpha-S2 | 9.197 | Major milk protein, produce casocidin-I that inhibits the growth of bacteria, plays role in the transport of calcium phosphate, source of bioactive peptides and amino acids, mammary gland specific protein |
CSN3 | Casein kappa | 8.658 | Major milk protein, micelle formation to transport calcium, source of bioactive peptides (casoplatelin inhibits platelet aggregation, casoxins have opioid activity) and amino acids, mammary gland specific |
LALBA | Lactalbumin, alpha- | 5.484 | Major milk protein, forms regulatory subunit of lactose synthase, enables lactose synthase to synthesize lactose, causes allergic reaction in some people, mammary gland specific |
GLYCAM1 | Glycosylation-dependent cell adhesion molecule 1 | 2.127 | Highly and specifically expressed in the lactating mammary gland, play role in cell adhesion molecule binding |
COX1 | Cytochrome c oxidase subunit 1 | 0.937 | Has catalytic activities, is a component of the respiratory chain that catalyzes the reduction of oxygen to water, subunits 1–3 form the functional core of the enzyme complex, belongs to the heme-copper respiratory oxidase family |
COX3 | Cytochrome c oxidase subunit 3 | 0.509 | Has catalytic activity, subunits I, II and III form the functional core of the enzyme complex, belongs to the cytochrome c oxidase subunit 3 family |
ATP6 | ATP synthase FO subunit 6 | 0.430 | Play role in the translocation of protons across the membrane, ATPase activity |
MT-ND3 | Mitochondrially encoded NADH dehydrogenase 3 | 0.344 | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain |
FABP3 | Fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) | 0.2921 | Play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters, belongs to calycin superfamily, fatty-acid binding protein family |
ND1 | NADH-ubiquinone oxidoreductase chain 1 | 0.298 | Catalytic activity, NADH dehydrogenase activity, belongs to the complex I subunit 1 family |
COII (MT-CO2) | Mitochondrially encoded cytochrome c oxidase II | 0.301 | Is the component of the respiratory chain that catalyzes the reduction of oxygen to water |
MT-ATP8 | Mitochondrially encoded ATP synthase 8 | 0.252 | Unknown function. Is a player in metabolic pathways. |
MT-CYB | mitochondrially encoded cytochrome b | 0.248 | Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (by similarity) |
HSTN | Histatherin | 0.232 | Unknown |
SPP1 | Secreted phosphoprotein 1 | 0.163 | Acts as a cytokine, involved in enhancing production of interferon-gamma and interleukin-12, reduces production of interleukin-10, is essential in the pathway that leads to type I immunity, probably involved in cell adhesion, belongs to the osteopontin family |
MT-ND4 | Mitochondrially Encoded NADH Dehydrogenase 4 | 0.152 | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain |
RPLP1 | Ribosomal protein, large, P1 | 0.144 | Is a functional constituent of ribosomes and functions in translational elongation |
MFGE8 | Milk fat globule-EGF factor 8 protein | 0.152 | Specific ligand for alpha-v/beta-3 and alpha-v/beta-5 receptors, Contributes to phagocytic removal of apoptotic cells in many tissues |
SCD | Stearoyl-CoA desaturase (delta-9-desaturase) | 0.133 | Catalyzes the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA, belongs to the fatty acid desaturase family |
RNASE1 | Ribonuclease, RNase A family, 1 | 0.099 | Nucleic acid binding and ribonuclease A activity |
EEF1A1 | Eukaryotic translation elongation factor 1 alpha 1 | 0.099 | promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis, involved in Th1 (T helper 1) cytokine production |