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Fig. 1 | BMC Genomics

Fig. 1

From: Nonlinear transcriptomic response to dietary fat intake in the small intestine of C57BL/6J mice

Fig. 1

Comparison between classical and novel approach for identifying differentially expressed genes. We use as a reference the case study of mice fed with four levels of fat representing 10, 20, 30 and 45 % of total energy intake [18]; gene expression is measured in three sections of small intestine: a In the classical approach, the total number of differentially expressed genes is determined by comparing the control diet (10 E%) with treatments (20, 30 and 45 E%). Gene counts refer to results of de Wit et al. [18]; y-axis on log10 scale. b In the novel approach, all expression levels of each gene (in the three sections) are considered to fit linear or nonlinear (i.e., logarithmic and exponential, in this case) response types. Three hypothetical patterns are described: (I) gene type A preserves a linear response in the three sections of small intestine; (II) gene type B displays overload (i.e., logarithmic response) in the proximal and middle sections; (III) gene type C shows exponential responses in most downstream sections (i.e., middle and distal parts of small intestine). Transcriptomic response of gene type A is gene-specific while the patterns observed for gene type B and C are section-specific

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