Nonlinear transcriptomic response to dietary fat intake in the small intestine of C57BL/6J mice

BMC Genomics

Table 1 Count of genes that responded to fat intake in a significant, dose-dependent manner

Response (Gene expression vs. Fat intake)	Proximal			Middle			Distal
Response (Gene expression vs. Fat intake)	Gene (count)	Relative %	GOBP (count)	Gene (count)	Relative %	GOBP (count)	Gene (count)	Relative %	GOBP (count)
Linear	1053	53.29	25	1410	56.65	27	185	59.11	26
Logarithmic	678	34.31	1	458	18.40	22	26	8.31	-
Exponential	139	7.03	-	499	20.05	9	84	26.84	8
Quadratic	61	3.09	-	87	3.50	7	9	2.88	-
Cubic	45	2.28	-	35	1.41	2	9	2.88	-

Results were extracted using the limma library and are specific to each section of small intestine; adjusted p-value < 0.1. Genes are classified based on the mathematical function used to fit their expression in response to fat intake (linear, logarithmic, exponential, quadratic or cubic). For each section, we summarize the relative percentage of genes characterized by the five response types (%) and the number of significant GO terms (Biological Processes - GOBP) found with hypergeometric test (adjusted p-value < 0. 1). Only GOBP terms with at least six differentially expressed genes (in the whole small intestine) have been taken into account

ISSN: 1471-2164