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Table 2 Over-represented Gene Ontology Biological Process (GOBP) terms that can be found in various intestinal sections

From: Nonlinear transcriptomic response to dietary fat intake in the small intestine of C57BL/6J mice

Section and Responses GO ID GOBP Proximal Middle Distal
Set Size Hits Adjusted p-value Set Size Hits Adjusted p-value Set Size Hits Adjusted p-value
Prox-Mid-Dist (all linear) GO:0006953 Acute-phase response 22 5 0.09 22 6 0.08 21 3 0.03
Prox-Mid (lm - lm) GO:0006629 Lipid metabolic process 184 33 <0.01 183 46 <0.01    
GO:0006631 Fatty acid metabolic process 68 19 <0.01 67 28 <0.01    
GO:0006635 Fatty acid beta-oxidation 21 9 <0.01 21 11 <0.01    
GO:0006637 Acyl-CoA metabolic process 19 7 <0.01 19 6 0.04    
GO:0007040 Lysosome organization 18 5 0.03 18 6 0.04    
GO:0015031 Protein transport 386 45 0.01 387 60 <0.01    
GO:0022900 Electron transport chain 69 14 <0.01 69 18 <0.01    
GO:0055085 Transmembrane transport 390 42 0.07 391 57 0.02    
Prox-Mid (lm - log) GO:0042632 Cholesterol homeostasis 33 11 <0.01 33 4 0.10    
Prox-Mid (lm - exp) GO:0030301 Cholesterol transport 15 7 <0.01 15 4 0.03    
Mid-Dist (lm - lm) GO:0006520 Cellular amino acid metabolic process     16 5 0.07 16 2 0.05
GO:0016042 Lipid catabolic process     69 14 0.05 69 5 0.03
GO:0051262 Protein tetramerization     17 5 0.09 17 2 0.05
Mid-Dist (lm - exp) GO:0043154 Negative regulation of caspase activity     36 10 0.02 36 2 0.06
Mid-Dist (log - lm) GO:0006644 Phospholipid metabolic process     17 4 0.01 17 2 0.05
GO:0006749 Glutathione metabolic process     24 4 0.04 24 2 0.08
GO:0045859 Regulation of protein kinase activity     16 4 0.01 16 2 0.05
  1. We summarize total number of genes corresponding to a given GO term in the microarray gene expression (gene set size, labelled as Set Size), count of genes extracted with our analysis (observed hits, labelled as Hits) and adjusted p-values (values have been rounded-up to two decimal points; adjusted p-value < 0.1). Intestine sections: Prox = proximal; Mid = middle; Dist = distal. Response types: lm = linear; log logarithm; exp = exponential. GOBP terms showing quadratic and cubic response types have been excluded as they can be found in the middle section only (i.e., there are no spatial trends along the small intestine axis; see Table 1)