Fig. 6
From: Clam focal and systemic immune responses to QPX infection revealed by RNA-seq technology
Overview of immune-related enriched pathways of differentially expressed (DE) transcripts during M. mercenaria response to QPX. a Schematic diagram of enriched pathways and their interactions. Only pathway components encoded by DE transcripts (shown in text boxes) are presented within each enriched KEGG pathway (framed in orthogonal polygons). Arrows display possible interactions (e.g., activation, inhibition) between pathway components. b Overview of DE transcripts expression associated with enriched pathways in nodule, non-nodule and healthy M. mercenaria tissues. The red and green heatmap values indicate log2 fold of relative expression levels for individual transcripts. Arp2/3: actin related protein 2/3 complex; CtBP: C-terminal binding protein; CAMK2: calcium/calmodulin-dependent protein kinase (CaM kinase) II; CycD: cyclin D1(CCND1); ECM: von Willebrand factor; ENDO-G: endonuclease G; FAK: focal adhesion kinase; FYN: tyrosine-protein kinase; HES1: hairy and enhancer of split 1; IAP: baculoviral IAP repeat-containing protein, cIAPs; ITGA: intergrin alpha; ITGB: intergrin beta; MLCP: serine/threonine-protein phosphatase PP1 catalytic subunit; NRXN: neurexin; NCSTN: nicastrin; Rac: Ras-related C3 botulinum toxin substrate; ROCK: Rho-associated protein kinase; RTK: proto-oncogene tyrosine-protein kinase; SELE: selectin, endothelial cell; SELP: selectin, platelet; TRAIL: tumor necrosis factor ligand superfamily member 10); WNT: wingless-type MMTV integration site family