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Fig. 4 | BMC Genomics

Fig. 4

From: A streamlined tethered chromosome conformation capture protocol

Fig. 4

Differences in prevalence of intra- and inter-chromosomal contacts. Contacts detected in aggregated N2 DpnII experiments (total of ~18M junctions) were used to construct an interaction frequency matrix with resolution of 50KB. a, b, c show sections of this chart under different magnifications. For each square in the matrix we calculated an expected number of contacts (based on the product of sequence read coverage for the two regions amongst all “junctional” reads) and compared these with the quantity of the observed “junctional” reads between the two indicated regions. We have plotted the frequencies of observed/expected ratios in intra- and inter-chromosomal junctions for each bin of width 0.001 in observed/expected value. Junctions mapping to ribosomal RNA sequence on chromosome I were excluded from the calculation

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