Table 1 Antioxidant-associated genes upregulated by cAMP in astrocytes (fold-change)

Catalase

Cat (2.2)

Superoxidase dismutases

Sod2 (1.4), Sod3 (5.3)

Peroxiredoxins and sulfiredoxins

Prdx1 (1.8), Prdx2 (1.5), Prdx5 (1.5), Srxn1 (4.1)

Cystine/glutamate transporter

Slc7a11 (9.6)

Glutamate-cysteine ligases

Gclc (5.3), Gclm (3.1)

Gluthatione synthetase and transferases

Gss (1.5), Gsta1 (15.7), Gsta2 (6.9), Gsta3 (6.6), Gsta4 (2.3), Gstm5 (1.6), Mgst1 (4.4), Mgst2 (7.7)

Glutathione peroxidases and reductases

Gpx4 (1.6), Gsr (1.5)

NADPH-quinone oxidoreductase and heme oxygenase

Nqo1 (4.4)

Thioredoxins and thioredoxin reductases

Txn2 (1.6), Txnrd1 (3.3)

Metallothioneins and selenoproteins

Mt1 (1.6), Mt2 (1.5), Sepp1 (1.3)

Ascorbate and glucose/dehydroascorbate transporters

Slc23a2 (4.5), Slc2a1 (3.9), Slc2a4 (1.4), Slc2a8 (1.7), Slc2a13 (2.2)

α-tocopherol transfer protein

Ttpa (2.2)