Table 1 Automated summary for CD44 (case study 1). CD44 was the 2 ^nd ranked epicenter specific to the perturbed condition. The table shows the nodes in the immediate influence zone (up to 2 hops up/downstream) of CD44 which showed significant differential expression (2-fold). The first row corresponds to the input node, CD44. In the subsequent rows, the first column shows the differentially expressed gene (DEG). If the DEG is more than 1 hop away from CD44, the intermediate nodes on the unweighted shortest path are described in columns 6 onwards

CD44

input_node

0

1.0776225906

unique to perturbed CSHAN

L1CAM

down_CD44

2

4.3995043553

unique to perturbed CSHAN

EZR

1.4077313131

False

common to both CSHANs

CBLB

down_CD44

2

2.7450193138

unique to perturbed CSHAN

EGFR

0.9625043727

False

common to both CSHANs

TNNT1

down_CD44

2

0.3519677136

unique to control CSHAN

FYN

1.047836048

False

common to both CSHANs

RPS6KA2

down_CD44

2

3.7937197295

unique to perturbed CSHAN

EGFR

0.9625043727

False

common to both CSHANs

NEDD9

down_CD44

2

0.4699818669

not in any CSHAN

FYN

1.047836048

False

common to both CSHANs

TFPI

down_CD44

2

2.7743880699

not in any CSHAN

MMP7

0.1323159054

True

not in any CSHAN

MBNL3

down_CD44

2

4.0574758277

not in any CSHAN

LCK

0.967172212

False

not in any CSHAN

IVNS1ABP

down_CD44

2

2.0134951539

common to both CSHANs

ARHGEF1

1.0053092034

False

not in any CSHAN

ITGB3

down_CD44

2

0.2450269938

not in any CSHAN

COL1A2

1.6105271705

False

common to both CSHANs

PLA2G4A

down_CD44

2

7.496384226

not in any CSHAN

COL1A2

1.6105271705

False

common to both CSHANs

FN1

down_CD44

2

2.2964207553

unique to perturbed CSHAN

COL1A2

1.6105271705

False

common to both CSHANs

MEF2C

down_CD44

2

2.2667831761

unique to perturbed CSHAN

CD74

0.9449408306

False

not in any CSHAN

PTK2

down_CD44

2

0.2821339725

not in any CSHAN

EGFR

0.9625043727

False

common to both CSHANs

CHN1

down_CD44

2

3.1958019401

unique to perturbed CSHAN

TGFBR1

0.7284950123

False

common to both CSHANs

EGR1

down_CD44

2

2.1681746909

common to both CSHANs

ARHGEF1

1.0053092034

False

not in any CSHAN

SRGN

down_CD44

1

0.4947740703

not in any CSHAN

OCLN

down_CD44

2

2.9381790192

not in any CSHAN

TGFBR1

0.7284950123

False

common to both CSHANs

ADAM12

down_CD44

2

2.3217184015

unique to perturbed CSHAN

IGFBP3

1.9432883668

False

common to both CSHANs

TIMP1

down_CD44

2

0.4692561311

unique to control CSHAN

MMP1

0.9852575467

False

not in any CSHAN

MMP7

down_CD44

1

0.1323159054

not in any CSHAN

L1CAM

up_CD44

2

4.3995043553

unique to perturbed CSHAN

ANK1

0.7930398677

False

not in any CSHAN

ITGB3

up_CD44

2

0.2450269938

not in any CSHAN

COL1A2

1.6105271705

False

common to both CSHANs

MMP7

up_CD44

1

0.1323159054

not in any CSHAN