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Table 4 Comparison of ensemble of low-cost on →off paths across H-Ras WT and variants

From: Computing energy landscape maps and structural excursions of proteins

Sequence

m a x_n n_d i s t (Ã…)

(μ,σ)Cost (REU)

(μ,σ)Highest Energy (REU)

(μ,σ)Nr. Edges

WT

1.45/10

(418.3, 106.)

(–203.5, 25.1)

(101.3, 16.1)

 

1.45/7.5

(127.6, 7.90)

(–277.3, 15.2)

(64.2, 15.6)

G12S

1.45/10

—

—

—

 

1.45/7.5

(143, 40.9)

(–259, 92)

(73, 22)

G12C

1.45/10

—

—

—

 

1.45/7.5

(266.4, 18.2)

(–139.3, 24.4)

(60, 9.8)

G12D

1.45/10

—

—

—

 

1.45/7.5

(140.4, 15.5)

(–253.9, 15.9)

(54.6, 8.6)

G12V

1.45/10

—

—

—

 

1.45/7.5

(132.3, 13.5)

(–236.3, 83.4)

(64.6, 13.)

Q61L

1.45/10

—

—

—

 

1.45/7.5

(161.3, 45.2)

(–240.7, 21.8)

(64.1, 9.2)

Y32CC118S

1.45/10

—

—

—

 

1.45/7.5

(158.2, 18.9)

(–257.5, 18.1)

(63.9, 10.2)

R164AQ165V

1.45/10

—

—

—

 

1.45/7.5

(159.7, 21.3)

(–245.6, 23.8)

(65.9, 7.1)