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Fig. 4 | BMC Genomics

Fig. 4

From: Network-based bioinformatics analysis of spatio-temporal RNA-Seq data reveals transcriptional programs underpinning normal and aberrant retinal development

Fig. 4

RNA-Seq revealed progression of biological programs across normal and aberrant retinal development. a Schematized representation of kinetics of the molecular programs identified by RNA-Seq (E16CE-P0CE- P0NE) is represented with different colors and the shapes represent the gene expression kinetics. b Extension of our temporal analysis strategy to P21-Nrl-WT and P21-Nrl-KO by comparing them to P0 (P0CE + P0NE) revealed molecular programs in normal development (P21-Nrl-WT) and unique programs in aberrant development (P21-Nrl-KO). c Schematic representation of a cell at P0, where the cytoplasm and the nucleus are temporally synchronized and the cell with dotted line shows that the nuclear transcriptome is shifted forward temporally compared to that of the cytoplasm

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BMC Genomics

ISSN: 1471-2164

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