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Table 1 Top 15 genes normally upregulated by HSF-1 in response to HS

From: The genome-wide role of HSF-1 in the regulation of gene expression in Caenorhabditis elegans

 

Transcript ID

Gene Name

Fold Change (log2) hsf-1(+);+HS vs. control

Description (WormBase)

1

F44E5.5

F44E5.5

8.06

F44E5.5 encodes a member of the Hsp70 family of heat shock proteins

2

F44E5.4

F44E5.4

7.87

F44E5.4 encodes a member of the Hsp70 family of heat shock proteins

3

Y46H3A.3

hsp-16.2

7.53

hsp-16.2 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins

4

Y46H3A.2

hsp-16.41

7.41

hsp-16.41 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins

5

T27E4.2

hsp-16.11

7.31

hsp-16.11 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins

6

C12C8.1

hsp-70

7.15

hsp-70 encodes a heat-shock protein that is a member of the HSP70 family of molecular chaperones

7

T27E4.8

hsp-16.1

6.9

hsp-16.1 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins

8

T27E4.3

hsp-16.48

6.77

hsp-16.48 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins

9

Y38E10A.13

nspe-1

6.54

nspe-1 is a nematode-specific peptide that has an unknown function

10

T27E4.9

hsp-16.49

6.5

hsp-16.49 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins

11

F26H11.2

nurf-1

4.15

nurf-1 encodes the C. elegans ortholog of Drosophila NURF301, a component of the NURF chromatin remodeling complex

12

ZC21.10

ZC21.10

3.84

Unknown function

13

D2013.8

scp-1

3.68

scp-1 encodes PTC-related protein that contains a sterol-sensing domain related to human Sterol regulatory element binding protein (SREBP) cleavage activating protein

14

R107.5

R107.5

3.29

Unknown function

15

B0024.1

col-149

3.01

col-149 is predicted to be a structural constituent of the cuticle

  1. The transcript ID, gene name, fold change as compared to the hsf-1(+);-HS control, and description as provided from WormBase, are listed for the 15 genes with the highest positive fold changes in expression. A complete list of significantly upregulated transcripts is given (see Additional file 2: Table S1)