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Table 3 Top 15 genes normally upregulated by HSF-1 independently of HS

From: The genome-wide role of HSF-1 in the regulation of gene expression in Caenorhabditis elegans

 

Transcript ID

Gene Name

Fold Change (log2) control vs. hsf-1(-);-HS

Description (WormBase)

1

C55B7.4

acdh-1

4.62

acdh-1 encodes a short-chain acyl-CoA dehydrogenase. ACDH-1 is predicted to be a mitochondrial enzyme that catalyzes the first step of fatty acid beta-oxidation, and thus plays a key role in energy production

2

F59D8.1

vit-3

3.52

vit-3 encodes a vitellogenin, a precursor of the lipid-binding protein related to vertebrate vitellogenins and mammalian ApoB-100, a core LDL particle constituent

3

F59D8.2

vit-4

3.47

vit-4 is involved in embryo development and is predicted to have lipid transporter activity

4

C04F6.1

vit-5

3.39

vit-5 encodes a vitellogenin, a lipid-binding protein precursor related to vertebrate vitellogenins and mammalian ApoB-100, a core LDL particle constituent

5

K09F5.2

vit-1

3.38

vit-1 is predicted to have lipid transporter activity

6

Y40H7A.10

Y40H7A.10

3.37

Unknown function

7

K11G9.3

K11G9.3

3.15

K11G9.3 encodes an ortholog of human butyrylcholinesterase

8

F37B4.7

folt-2

3.06

folt-2 encodes a putative folate transporter and is orthologous to the human folate transporters SLC19A1, SLC19A2, and SLC19A3

9

F22A3.6

ilys-5

2.99

ilys-5 is involved in embryo development and is predicted to have lysozyme activity

10

ZC266.1

ZC266.1

2.76

ZC266.1 is predicted to have G-protein coupled receptor activity

11

F10D2.9

fat-7

2.64

fat-7 encodes an essential delta-9 fatty acid desaturase that is required for the synthesis of monounsaturated fatty acids

12

K10B2.2

K10B2.2

2.55

K10B2.2 encodes an ortholog of human cathepsin A and is predicted to have carboxypeptidase activity

13

Y52E8A.4

Y52E8A.4

2.46

Y52E8A.4 encodes an ortholog of human major facilitator superfamily domain containing 11

14

C08F11.8

ugt-22

2.44

ugt-22 encodes an ortholog of human UDP glucuronosyltransferase 1 family polypeptide, and is predicted to have transferase activity

15

F54F7.2

F54F7.2

2.44

Unknown function

  1. The transcript ID, gene name, and fold change in gene expression in the comparison of the control vs. hsf-1(-);-HS are listed for the top 15 genes normally upregulated by HSF-1 independently of HS. Gene descriptions, as provided from WormBase, are also listed. A complete list of the significantly altered transcripts is given (see Additional file 2: Table S1)