Fig. 2
From: Disrupted cooperation between transcription factors across diverse cancer types
The pair-wise TF cooperativity is mainly lost in tumor relative in normal. a The schema of TF cooperation change. TF pairs with significant coordination changes (>2SD) that only appeared in the highly coordinated list in tumor but not in normal were defined as “Gain”. TF pairs with significant coordination changes (>2SD) that only presented in the highly coordinated normal list were defined as “Loss”. TF pairs showing both in the tumor and normal list but opposite direction (e.g., positively correlated in tumor but inversely correlated in normal or vice versa) were classified as “Reverse”. b Bar plot depicts percentage of Loss, Gain and Reverse in TF cooperativity alteration