Table 1 Gene Ontology annotations of the differentially expressed hepatic genes with the Panther Classification Systema
Treatment | Gene symbol | Gene name | Treatment effect | Molecular function | Biological process | Protein class |
|---|---|---|---|---|---|---|
B9 | ||||||
  DLK1 | Delta-like 1 homolog (Drosophila) | Down-regulated | receptor activity extracellular matrix structural constituent receptor binding | transcription from RNA polymerase II promoter cell communication ectoderm development nervous system development intracellular protein transport receptor-mediated endocytosis regulation of transcription from RNA polymerase II promoter | membrane-bound signaling molecule receptor extracellular matrix structural protein | |
  MYOM1 | Myomesin-1 | Down-regulated | protein kinase activity structural constituent of cytoskeleton protein binding small GTPase regulator activity guanyl-nucleotide exchange factor activity | protein phosphorylation cell communication cell adhesion muscle contraction mesoderm development muscle organ development regulation of catalytic activity | non-receptor serine/threonine protein kinase non-receptor serine/threonine protein kinase guanyl-nucleotide exchange factor actin family cytoskeletal protein cell adhesion molecule | |
B12 | ||||||
  HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | Up-regulated | ligase activity | catabolic process cellular protein modification process proteolysis cellular process | ubiquitin-protein ligase | |
  SESN2 | Sestrin-2 | Up-regulated | oxidoreductase activity peroxidase activity | metabolic process cell cycle | Peroxidase | |
  GPNMB | glycoprotein (transmembrane) nmb | Up-regulated | receptor binding | cellular process | membrane-bound signaling molecule cell adhesion molecule | |
  IFI6 | Interferon alpha-inducible protein 6 | Up-regulated | Unassigned | Unassigned | Unassigned | |
  PPP1R3B | Protein phosphatase 1 regulatory subunit 3B | Up-regulated | phosphatase activity protein binding phosphatase regulator activity | glycogen metabolic process regulation of catalytic activity | phosphatase modulator | |
  ID1 | ID1 protein | Up-regulated | sequence-specific DNA binding transcription factor activity | transcription from RNA polymerase II promoter regulation of transcription from RNA polymerase II promoter | transcription factor | |
  IFI27 | interferon, alpha-inducible protein 27 | Up-regulated | Unassigned | Unassigned | Unassigned | |
  MEP1B | meprin A, beta | Up-regulated | oxidoreductase activity serine-type peptidase activity metallopeptidase activity receptor activity lipid transporter activity transmembrane transporter activity receptor binding enzyme regulator activity | immune system process proteolysis synaptic transmission cell-cell adhesion visual perception sensory perception ectoderm development mesoderm development skeletal system development angiogenesis nervous system development heart development blood coagulation lipid transport intracellular protein transport endocytosis vitamin transport regulation of catalytic activity | transporter apolipoprotein membrane-bound signaling molecule receptor metalloprotease serine protease oxidase metalloprotease serine protease extracellular matrix protein enzyme modulator cell adhesion molecule | |
  FUT5 | fucosyltransferase 5 (alpha (1,3) fucosyltransferase | Up-regulated | transferase activity, transferring glycosyl groups | protein glycosylation | glycosyltransferase | |
  G0S2 | G0/G1switch 2 | Up-regulated | Unassigned | Unassigned | Unassigned | |
  CDK5R1 | Cyclin-dependent kinase 5 activator 1 | Up-regulated | kinase activity protein binding kinase activator activity kinase regulator activity | protein phosphorylation cell cycle regulation of catalytic activity | kinase activator | |
  ISG15 | Ubiquitin-like protein ISG15 | Up-regulated | structural constituent of ribosome nucleic acid binding | proteolysis | ribosomal protein | |
 LOC515676 | NFX1-type zinc finger-containing protein 1-like | Up-regulated | peptidase activity protein binding serine-type endopeptidase inhibitor activity | proteolysis regulation of catalytic activity | serine protease inhibitor | |
  SPP1 | Osteopontin | Up-regulated | cytokine activity | immune system process cellular process cell adhesion cellular component morphogenesis cellular component organization | cytokine extracellular matrix protein defense/immunity protein cell adhesion molecule | |
  DLK1 | Delta-like 1 homolog (Drosophila) | Down-regulated | receptor activity extracellular matrix structural constituent receptor binding | transcription from RNA polymerase II promoter cell communication ectoderm development nervous system development intracellular protein transport receptor-mediated endocytosis regulation of transcription from RNA polymerase II promoter | membrane-bound signaling molecule receptor extracellular matrix structural protein | |
  MYOM1 | Myomesin-1 | Down-regulated | protein kinase activity structural constituent of cytoskeleton protein binding small GTPase regulator activity guanyl-nucleotide exchange factor activity | protein phosphorylation cell communication cell adhesion muscle contraction mesoderm development muscle organ development regulation of catalytic activity | non-receptor serine/threonine protein kinase non-receptor serine/threonine protein kinase guanyl-nucleotide exchange factor actin family cytoskeletal protein cell adhesion molecule | |
  MT1E | Metallothionein MT1E | Down-regulated | Unassigned | Unassigned | Unassigned | |
  NEFH | ortholog Uncharacterized protein (Fragment) NEFH ortholog | Down-regulated | Unassigned | Unassigned | Unassigned | |
  SFRP1 | Secreted frizzled-related protein 1 | Down-regulated | receptor activity protein binding | reproduction cell communication single-multicellular organism process nervous system development response to stimulus regulation of biological process | signaling molecule G-protein coupled receptor | |
  KIAA1324 | KIAA1324 ortholog | Down-regulated | Unassigned | Unassigned | Unassigned | |
  MGC126945 | Uncharacterized protein | Down-regulated | receptor activity | B cell mediated immunity antigen processing and presentation cellular defense response | immunoglobulin receptor superfamily immunoglobulin receptor superfamily major histocompatibility complex antigen | |
  MT1A | Metallothionein-1A MT1A | Down-regulated | Unassigned | Unassigned | Unassigned | |
B9 + B12 | ||||||
  SAA3 | Serum amyloid A protein | Down-regulated | lipid transporter activity transmembrane transporter activity | immune system process lipid transport | transporter apolipoprotein defense/immunity protein | |
 LOC100126815 | MHC class I-like family A1 | Down-regulated | receptor activity | B cell mediated immunity antigen processing and presentation cellular defense response | immunoglobulin receptor superfamily immunoglobulin receptor superfamily major histocompatibility complex antigen | |
  ACMSD | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase | Down-regulated | Unassigned | Unassigned | Unassigned | |
  THRSP | THRSP protein | Down-regulated | Unassigned | Unassigned | Unassigned | |
  MGC126945 | Uncharacterized protein | Down-regulated | receptor activity | B cell mediated immunity antigen processing and presentation cellular defense response | immunoglobulin receptor superfamily immunoglobulin receptor superfamily major histocompatibility complex antigen | |
  MT1A | Metallothionein-1A MT1A | Down-regulated | Unassigned | Unassigned | Unassigned | |
  C4H7orf57 | chromosome 4 open reading frame, human C7orf57 | Down-regulated | Unassigned | Unassigned | Unassigned | |
  CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit | Down-regulated | cation transmembrane transporter activity | cation transport protein targeting | Unassigned | |
  GSTA5 | Glutathione S-transferase | Down-regulated | Unassigned | Unassigned | Unassigned | |
 LOC509034 | feline leukemia virus subgroup C receptor-related protein 2-like | Down-regulated | transmembrane transporter activity | transport | transporter | |
  NHEDC1 | solute carrier family 9, subfamily B (cation proton antiporter 2), member 1 | Down-regulated | Unassigned | Unassigned | Unassigned | |
  SH3YL1 | SH3 domain-containing YSC84-like protein 1 | Down-regulated | structural constituent of cytoskeleton actin binding | cellular process | non-motor actin binding protein | |
  HP | Haptoglobin | Down-regulated | serine-type peptidase activity calcium ion binding calmodulin binding calcium-dependent phospholipid binding | gamete generation complement activation proteolysis cellular process blood circulation response to stress blood coagulation | serine protease serine protease complement component annexin calmodulin | |
  NGEF | neuronal guanine nucleotide exchange factor | Down-regulated | Unassigned | Unassigned | Unassigned | |
  LGALS3 | Lectin, galactoside-binding, soluble, 3 | Up-regulated | receptor binding | cellular process | signaling molecule cell adhesion molecule | |
 LOC524810 | IgM | Up-regulated | Unassigned | Unassigned | Unassigned | |
  LOXL4 | Lysyl oxidase homolog 4 | Up-regulated | oxidoreductase activity serine-type peptidase activity receptor activity | macrophage activation apoptotic process proteolysis cell communication cell-cell adhesion neurological system process cellular defense response extracellular transport negative regulation of apoptotic process | receptor serine protease oxidase serine protease | |
  PYCR1 | Pyrroline-5-carboxylate reductase 1, mitochondrial | Up-regulated | oxidoreductase activity | cellular amino acid biosynthetic process | reductase | |
  MSMB | Uncharacterized protein | Up-regulated | hormone activity |  | peptide hormone | |
  IGLL1 | immunoglobulin lambda-like polypeptide 1 | Up-regulated | antigen binding | B cell mediated immunity hemopoiesis response to stimulus | Immunoglobulin | |
  MT1E | Metallothionein MT1E | Down-regulated | Unassigned | Unassigned | Unassigned | |
  GPNMB | glycoprotein (transmembrane) nmb | Up-regulated | receptor binding | cellular process | membrane-bound signaling molecule cell adhesion molecule | |