Fig. 3
From: Predictive computational phenotyping and biomarker discovery using reference-free genome comparisons
Going beyond k-mers: This figure shows the location, on the katG gene, of each k-mer targeted by the isoniazid model (rule and equivalent rules). All the k-mers overlap a concise locus, suggesting that it contains a point mutation that is associated with the phenotype. A multiple sequence alignment revealed a high level of polymorphism at codon 315 (shown in red). The wild-type sequence (WT), as well as the resistance conferring variants S315G, S315I, S315N and S315T, were observed. The rule in the model captures the absence of WT and thus, includes the occurrence of all the observed variants