Integrative analysis of somatic mutations and transcriptomic data to functionally stratify breast cancer patients

BMC Genomics

Table 1 Statistical tests on the patient subtypes enriched in each group from K = 3 clustering results. No statistic test was performed for HER2 (and TN) status, due to the fact that more than 25 % patients do not contain HER2 status

	Total	ER+	ER-	χ² adj-P value	PR+	PR-	χ² adj-P value	HER2+	HER2-	Triple -
Group1	41	14	26	0.00075	13	26	0.00658	8	23	16
Group2	304	233	68	0.700	205	95	0.488	55	158	28
Group3	100	85	12	0.0619	68	30	0.6476	15	53	5
Total (with sig mutation and matching RNAseq)	445	332	106		286	151		78	235	49
Total in TCGA	876	634	187		548	267		136	447	90

ISSN: 1471-2164