Table 1 The 15 genomics regions associated with 207 tumor suppressor genes (TSGs) with frequent copy number losses (CNLs)
From: Concordance of copy number loss and down-regulation of tumor suppressor genes: a pan-cancer study
Cytoband | p-value | q-value | # TSGs | TSG list |
|---|---|---|---|---|
3p21.3 | 5.98E-19 | 3.48E-16 | 14 | CTDSPL, CYB561D2, LIMD1, MST1R, NPRL2, PTPN23, RASSF1, RBM5, RBM6, RHOA, SEMA3B, SEMA3F, TUSC2, ZMYND10 |
8p22 | 4.48E-09 | 9.78E-07 | 7 | CCAR2, DLC1, LZTS1, MIR383, MTUS1, SOX7, ZDHHC2 |
11p15.5 | 5.05E-09 | 9.78E-07 | 10 | CDKN1C, H19, MIR210, MIR483, NUP98, RNH1, SIRT3, TRIM3, TSPAN32, TSSC4 |
17p13.1 | 5.30E-08 | 7.71E-06 | 9 | ALOX15B, BCL6B, GABARAP, MIR195, MIR497, TNK1, TP53, XAF1, ZBTB4 |
19p13.3 | 2.52E-06 | 2.93E-04 | 10 | AMH, DAPK3, DIRAS1, FZR1, GADD45B, PLK5, SIRT6, STK11, TCF3, TNFSF9 |
8p21.3 | 3.45E-06 | 3.34E-04 | 5 | DOK2, MIR320A, PIWIL2, PPP3CC, RHOBTB2 |
3p21.31 | 3.63E-05 | 3.01E-03 | 6 | CDCP1, LTF, MIR1226, SETD2, SMARCC1, TDGF1 |
3p21.1 | 1.49E-04 | 1.02E-02 | 4 | ACY1, CACNA2D3, MIR135A1, MIRLET7G |
6q26 | 1.58E-04 | 1.02E-02 | 3 | MAP3K4, IGF2R, PACRG |
10q24-q25 | 2.09E-04 | 1.16E-02 | 2 | CHUK, MXI1 |
8p21 | 2.19E-04 | 1.16E-02 | 3 | BNIP3L, EXTL3, TNFRSF10A |
17p13.3 | 2.40E-04 | 1.16E-02 | 5 | ALOX15, MNT, MYBBP1A, PAFAH1B1, VPS53 |
22q13.31 | 2.62E-04 | 1.17E-02 | 4 | FBLN1, MIRLET7B, MIRLET7A3, PPARA |
9p21 | 7.46E-04 | 3.10E-02 | 3 | CDKN2A, CDKN2B, MTAP |
3p21 | 1.08E-03 | 4.19E-02 | 3 | GNAT1, MST1, PBRM1 |