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Fig. 3 | BMC Genomics

Fig. 3

From: Genome-wide association study to identify potential genetic modifiers in a canine model for Duchenne muscular dystrophy

Fig. 3

Association between tetanic flexion and loci on CFA9. In panel A, a Manhattan plot spotlights 16 significant SNPs (p < 0.01) associated with tetanic flexion (in green), which suggest a relationship between this biomarker and one or more loci on CFA9. These SNPs are clustered between bases 51735859–53937266 on CFA9; this region is illustrated in panel B. Panel C shows LD within this specific region in the GRMD dogs evaluated in this study. The 16 significant SNPs are again spotlighted here, with green rectangles around the SNP names. Gene RAPGEF1 is located within a region that is in LD with several of these significant SNPs; qPCR results confirmed that the expression of this gene in the cranial tibialis is associated with tetanic flexion

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BMC Genomics

ISSN: 1471-2164

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