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Table 3 Pathway enrichment analysis for pathways regulated by falcarinol and panaxydol (P-value < 0.01) after post-hoc analysis and significantly different genes related to the pathways

From: Determining the mode of action of anti-mycobacterial C17 diyne natural products using expression profiling: evidence for fatty acid biosynthesis inhibition

Treatment

Pathways

P-value

Genes in Pathway

Falcarinol

Threonine biosynthesis

5.3E-05

MSMEG 6286, thrC, thrB, MSMEG 4957, asd, MSMEG6257

Ectoine biosynthesis

6.1E-05

asd, MSMEG 6257, ectC, ectA, ectB

Superpathway of methionine biosynthesis (by sulfhydrylation)

4.4E-04

MSMEG 4528, metE, metX, MSMEG 1652, MSMEG 4657, asd, MSMEG 6257, MSMEG 6286

Isoleucine biosynthesis I

4.4E-04

ilvA, ilvH, thrC, thrB, MSMEG 4657, asd, MSMEG 6257, MSMEG 6286

Methionine Biosynthesis

2.0E-03

metE, MSMEG 4957, asd, MSMEG 6257, MSMEG 6286, MSMEG 4528, metX, MSMEG 1652

Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis

2.1E-03

MSMEG 6386, MSMEG 6399, MSMEG 6382, MSMEG 6401, glf, MSMEG 4947

Homoserine biosynthesis

3.0E-03

MSMEG 4957, asd, MSMEG 6257

Superpathway of methionine biosynthesis (transsulfuration)

4.7E-03

metE, MSMEG 4957, asd, MSMEG 6257, MSMEG 6286

Unusual Fatty Acid Biosynthesis

5.5E-03

MSMEG 1350, MSMEG 1351, MSMEG 3538

Cyclopropane Fatty Acids Biosynthesis

9.3E-03

MSMEG 1350, MSMEG 1351, MSMEG 3538

Panaxydol

Ectoine biosynthesis

3.8E-03

MSMEG 6257, ectC, ectA, ectB

Urea degradation II

3.8E-03

MSMEG 1093, ureC, ureB, ureA

Pyruvate fermentation to acetate VII

5.1E-03

pta, ackA, MSMEG 4646

Pyruvate fermentation to acetate I

5.1E-03

pta

Methionine Biosynthesis

6.3E-03

metE, metN, MSMEG 6257, MSMEG 6286, MSMEG 4528, MSMEG 4527, metXm MSMEG 1652

Superpathway of methionine biosynthesis (by sulfhydrylation)

7.7E-03

MSMEG 4528, MSMEG 4527, metE, metX, MSMEG 1652, MSMEG 6257, MSMEG 6286

Unusual Fatty Acid Biosynthesis

9.7E-03

MSMEG 1205, MSMEG 1350, MSMEG 1351, MSMEG 3538

Cyclopropane Fatty Acids Biosynthesis

9.7E-03

MSMEG 1205, MSMEG 1350, MSMEG 1351, MSMEG 3538

Urate biosynthesis/inosine 5′-phosphate degradation

9.7E-03

MSMEG 1701, MSMEG 4308, guaB, MSMEG 1603