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Fig. 1 | BMC Genomics

Fig. 1

From: Pangenome and immuno-proteomics analysis of Acinetobacter baumannii strains revealed the core peptide vaccine targets

Fig. 1

Schematic flow chart for the identification of putative core vaccine candidates in Acinetobacter baumannii. Sequences retrieved from NCBI were explored to get insight into the pan- and core genome of the strains. The evolutionary relationship between strains based on 16srRNA sequences was estimated. An elaborative inter- and intra-proteome comparison was executed followed by pan-core tree generation. Core proteome was subjected to reverse vaccinology approaches (sub-cellular localization, molecular weight estimation, essentiality, virulence, non-host homologs and trans-membrane helices) in order to prioritize efficient vaccine targets against A. baumannii. Subsequently, functional annotation of potential targets, the surface topology of predicted epitopes and their interactions with other proteins was determined

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