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Fig. 8 | BMC Genomics

Fig. 8

From: The Rat microRNA body atlas; Evaluation of the microRNA content of rat organs through deep sequencing and characterization of pancreas enriched miRNAs as biomarkers of pancreatic toxicity in the rat and dog

Fig. 8

Histopathologic assessment of the pancreases of dogs treated with caerulein. Marshall beagle dogs were treated with 3, 15 and 45 ug/kg of caerulein and histopathologic assessment of organs was performed at 24 and 72 h with dose, time and animal number indicated on the x-axis and the grade of injury indicated on the y-axis (pink indicates minimal injury and green indicates moderate injury). Pancreatic degeneration/necrosis was not noted in dogs treated with 3ug/kg of caerulein. Pancreatic degeneration/necrosis was noted in 1 dog at 24 h in the 15ug/kg group and displayed dose dependent increases in severity at 24 and 72 h in the 45ug/kg group

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