Fig. 8From: The Rat microRNA body atlas; Evaluation of the microRNA content of rat organs through deep sequencing and characterization of pancreas enriched miRNAs as biomarkers of pancreatic toxicity in the rat and dogHistopathologic assessment of the pancreases of dogs treated with caerulein. Marshall beagle dogs were treated with 3, 15 and 45 ug/kg of caerulein and histopathologic assessment of organs was performed at 24 and 72Â h with dose, time and animal number indicated on the x-axis and the grade of injury indicated on the y-axis (pink indicates minimal injury and green indicates moderate injury). Pancreatic degeneration/necrosis was not noted in dogs treated with 3ug/kg of caerulein. Pancreatic degeneration/necrosis was noted in 1 dog at 24Â h in the 15ug/kg group and displayed dose dependent increases in severity at 24 and 72Â h in the 45ug/kg groupBack to article page