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Fig. 9 | BMC Genomics

Fig. 9

From: The Rat microRNA body atlas; Evaluation of the microRNA content of rat organs through deep sequencing and characterization of pancreas enriched miRNAs as biomarkers of pancreatic toxicity in the rat and dog

Fig. 9

Clinical chemistry and serum miRNA analysis of caerulein treated dogs. Dogs treated with 3, 15 and 45 ug/kg of caerulein were examined for clinical chemistry and serum miRNA changes (doses are indicated by red, green and blue respectively). Time is indicated on the x-axis and the log 2 of the fold change, the mean as well as 95 % confidence interval are indicated on the y-axis.. miRNAs were increased in the serum of dogs trreated with 3ug/kg of caerulein prior to increases in amylase and lipase. miRNAs were dose dependently increased in the serum of dogs treated with 15 and 45 ug/kg of caerulein and correlated to amylase and lipase increases while miR-216a-5p remained elevated until 24 h. Values are normalized to vehicle and to the cel-miR-55-3p spike in

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BMC Genomics

ISSN: 1471-2164

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