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Table 1 Mean histone enrichment for the 10 histone modifications of genes according to their expression divergence between normal and cancer condition

From: The transposable element environment of human genes is associated with histone and expression changes in cancer

  

Down-regulated genes

Up-regulated genes

Histone modification

Normal

Cancer

Wilcoxon paired tests p-values

Normal

Cancer

Wilcoxon paired tests p-values

activating

H3K27ac

8.05*

7.35

<2.2e-16

13.46*

9.11

<2.2e-16

H3K9ac

8.63*

5.92

<2.2e-16

7.66*

7.39

2.78e-13

H3K36me3

2.91*

2.49

<2.2e-16

2.49*

1.65

<2.2e-16

H3K4me1

5.58*

5.28

8.99e-5

6.09

6.28*

<2.2e-16

H3K4me2

9.74

9.51

0.1682

8.06

11.10*

<2.2e-16

H3K4me3

6.83*

5.73

0.0002763

6.65

9.42*

<2.2e-16

H3K79me2

4.03*

1.92

<2.2e-16

2.97

4.46*

<2.2e-16

repressing

H3K27me3

1.76

5.86*

<2.2e-16

3.54

3.35

0.009098

H3K9me3

2.16*

0.96

<2.2e-16

1.69*

1.40

3.46e-7

H4K20me1

1.27

1.52*

5.56e-9

0.92

2.97*

<2.2e-16

  1. *Significantly more enrichment (p-value < 0.0025)