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Fig. 2 | BMC Genomics

Fig. 2

From: The transcriptional and splicing landscape of intestinal organoids undergoing nutrient starvation or endoplasmic reticulum stress

Fig. 2

Induction of an ER stress transcriptional program in thapsigargin-stimulated enteroids. a Scatterplot of the expression of ER stress response classified genes. Genes above the top red line represent a 2.5-fold increase in expression, while genes below the bottom red line represent genes down-regulated 2.5-fold. b Alternative splicing of transcription factor gene Xbp1 upon thapsigargin treatment, visualized via integrated genome browser (IGV). c Venn diagram analysis of 651 genes upregulated more than 2.5 fold upon 4 h of thapsigargin treatment, categorized by gene function. d Gene list manually curated based on gene function from the group of 651 upregulated genes. e Venn diagram analysis of 245 genes down-regulated more than 2.5 fold upon 4 h of thapsigargin treatment, categorized by gene function. f Gene list manually curated based on gene function from the group of 245 downregulated genes

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