Table 5 The top-AID/APOBEC signature-linked Functional Annotations identified by systems biology approach (algorithm II; overlap with 5 individual target genes)

1

proliferation of cells

1.16E-16

AEBP1, AIF1, ALOX5, AR, ARMC10, BGN, C3AR1, CAMK2N1, CASP1, CCL5, CCR5, CD2, CD47, CD48, CD84, CD86, CDKN1A, CIITA, CLEC7A, COL1A1, COL6A1, COL6A2, CSF2RB, CTGF, CTSS, CYBB, DKK3, DLC1, DOCK2, EGFR, EMILIN1, ENG, EPS8, ESR1, FAS, FBN1, FCER1G, FN1, FOXP1, FYB, GBP2, HCK, HEXB, HLA-DPB1, ID1, ID2, ID3, IGFBP4, IGFBP7, IL10RA, IL15, IRF1, ITGAM, ITPR1, LAIR1, LAMB1, LCP2, LIMA1, LPAR3, LRIG1, LST1, MEIS1, MNDA, MTUS1, MUC16, NID2, NPAS3, NPDC1, PMEPA1, PMP22, PPAP2A, PRRX1, PSMB10, PTPRC, RARRES3, RHBDF1, RHOB, ROCK2, SAMSN1, SASH3, SDC2, SNAI2, SOX17, SPOCK1, SULF2, TIMP1, TLR3, TNFRSF14, TNFSF13B, VCAN, ZFP36

ALOX5, CASP1, CCL5, CIITA, CLEC7A, CTSS, GBP2, HLA-DPB1, IL15, IRF1, ITGAM, PSMB10, RARRES3, TLR3, TNFRSF14, TNFSF13B

AR, ARMC10, CD47, ESR1, LPAR3, LRIG1, MEIS1, MUC16, NPAS3, SOX17

CAMK2N1, CDKN1A, COL1A1, COL6A1, COL6A2, CTGF, DLC1, EGFR, ENG, EPS8, FAS, FOXP1, HEXB, ID1, ID2, ID3, IGFBP4, IGFBP7, LIMA1, MTUS1, NPDC1, PPAP2A, RHBDF1, RHOB, SDC2, SNAI2, SULF2, TIMP1, ZFP36

AEBP1, COL6A2, DKK3, DLC1, EMILIN1, FBN1, FN1, ID1, ID2, ID3, IGFBP4, ITPR1, LAMB1, LIMA1, PMEPA1, PMP22, PPAP2A, PRRX1, RHOB, SDC2, SNAI2, SULF2, VCAN

AIF1, C3AR1, CCL5, CCR5, CD2, CD48, CD84, CD86, CSF2RB, CYBB, DOCK2, FCER1G, FYB, HCK, IL10RA, LAIR1, LCP2, LST1, MNDA, PTPRC, SAMSN1, SASH3